ADRD_Brain_Aging Phase 1: single-nuclei RNA atlas between young and aged subjects in four brain regions Where 'young' subjects were between 20-30 years of age at time of death and 'aged' were 60-85 years of age at time of death Brain regions included for each subject are: Enorhinal cortex (EC), Middle Temporal Gyrus (MTG), Subventricular Zone (SVZ), and Putamen (PUT) Phase 2: future work Expansion in the number of subjects included and analyses using age as a continuous variable Focus on a single brain region for the expanded subject series Multiome
