Add proliferating neoplastic cell (CL:9900001)

[Copilot]

New term request for a neoplastic cell that is actively cycling, needed for HuBMAP CTann crosswalks (RIBCA).

New term: CL:9900001 — proliferating neoplastic cell

• Parent: CL:0001063 (neoplastic cell)
• Definition: A neoplastic cell that is in the cell cycle (i.e., actively cycling, rather than quiescent/non-proliferative), and can be identified by expression patterns of cell-cycle/proliferation regulators such as Ki-67, PCNA, and MCM2 in multiplexed tissue imaging. [PMID:35292783, PMID:26308893, PMID:28109167]
• Exact synonym: proliferating tumor cell [PMID:35292783]
• Related synonyms: cycling neoplastic cell [PMID:26308893], cycling tumor cell [PMID:28109167]
• Contributor: https://orcid.org/0000-0001-5208-3432

Original prompt

---

This section details on the original issue you should resolve

<issue_title>[NTR] proliferating tumor cell</issue_title>
<issue_description>Preferred term label
proliferating neoplastic cell

Synonyms (add reference(s), please)
proliferating tumor cell
cycling neoplastic cell
cycling tumor cell

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A tumor cell that is cycling.

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
CL:0001063 'neoplastic cell'

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
N/A

Your ORCID
https://orcid.org/0000-0001-5208-3432

Additional notes or concerns
Needed for HuBMAP CTann crosswalks (RIBCA)

</issue_description>

<agent_instructions>use the information in the ticket and create a new CL term</agent_instructions>

Comments on the Issue (you are @copilot in this section)

@nicolevasilevsky note, this was discussed at a previous CL call: [https://docs.google.com/document/d/1XvMbNvr0FEsdqGhg79BYCYEHSqUxRHMcvhbGizEAht8/edit?tab=t.0](https://www.google.com/url?q=https://docs.google.com/document/d/1XvMbNvr0FEsdqGhg79BYCYEHSqUxRHMcvhbGizEAht8/edit?tab%3Dt.0&sa=D&source=docs&ust=1772239049433944&usg=AOvVaw3QXqB4kO56V_NV6PVl8RBY) @RiveraAndrea83 definition: A neoplastic cell that is in the cell cycle (i.e., actively cycling, rather than quiescent/non-proliferative), and can be identified by expression patterns of cell-cycle/proliferation regulators such as Ki-67, PCNA, and MCM2 in multiplexed tissue imaging.

References:
PMID:35292783
PMID:26308893
PMID:28109167

Synonyms:

exact synonym: proliferating tumor cell PMID:35292783
related synonym: cycling neoplastic cell PMID:26308893
related synonym: cycling tumor cell PMID:28109167

• Fixes [NTR] proliferating tumor cell #3581

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