Launch the dashboard to interactively explore the response surfaces and identify the optimal extraction parameters for each solvent system.
📍 Note: For the best experience, use a desktop browser to interact with the 3D models.
This project showcases the digital transformation of a patented extraction process designed to valorize Aloe vera processing by-products. By applying Circular Economy principles, we transform discarded Aloe rind into a high-value cosmetic ingredient.
- Patented Technology: Co-inventor of the industrial method for standardized aloesin extraction. 🔗 Open Patent
- Green Chemistry: Optimized use of "Generally Recognized as Safe" (GRAS) alternative solvents: Ethanol, Propylene Glycol, and Glycerol.
- Target Bioactivity: Extracts optimized for skin-depigmenting formulations due to their potent anti-tyrosinase activity.
The industrial processing of Aloe vera (L.) Burm. f. generates vast amounts of rind as a byproduct. This project uses Response Surface Methodology (RSM) to bridge the gap between laboratory research and industrial application.
Reference: Añibarro-Ortega, M., et al. (2021). Biology, 10(10), 951.
The optimization was performed using a Central Composite Rotatable Design (CCRD) to maximize the recovery of Aloesin, which was precisely quantified using HPLC-DAD-ESI/MSn.
Target Response: Aloesin Content: Expressed in mg/g of extract.
Process Variables:
-
Time (
$t$ ): 10–210 min -
Temperature (
$T$ ): 25–95 °C -
Solvent Concentration (
$S$ ): 0–100 % (w/w)
| Solvent System | Time (min) | Temp (°C) | Solvent (%) | Max Yield(pred) (mg/g) | Max Yield(exp) (mg/g) | R2adj |
|---|---|---|---|---|---|---|
| Ethanol/Water | 92.9 | 55.9 | 0.0 | 48 ± 1 | 51 ± 4 | 0.9862 |
| Propylene Glycol/Water | 12.0 | 60.6 | 51.1 | 63 ± 2 | 65 ± 4 | 0.8976 |
| Glycerol/Water | 42.2 | 56.8 | 17.5 | 57 ± 2 | 61 ± 3 | 0.8699 |
- Waste Valorization: Converts a low-cost byproduct into a high-margin cosmetic active.
- Cost Reduction: Identifies precise T/t thresholds to optimize ROI and energy consumption.
- Proven Innovation: Based on a patented process, ensuring a unique competitive advantage.
- Python 3.x
- Streamlit (Interactive Dashboard)
- Statsmodels (OLS Regression & Cubic Modeling)
- Plotly (3D Surface Visualization)