Bayesian inference for Dose-Response Analysis (BiDRA)

BiDRA is a user-friendly web interface for dose-response curves analysis.

The interface is available through this URL: https://bidra.bioinfo.iric.ca/

We describe our Bayesian approach in this paper: https://academic.oup.com/bioinformatics/article/35/14/i464/5529233

Branches

The code for BiDRA as presented at ISMB 2019 can be found in the ismb_2019branch. Current developments are added to the masterbranch.

April 2020 : Inference of efficacy metrics given priors that are not exclusively gaussian (new models for activity and inhibition data)

Dependencies

• Python3
• PyStan (and Stan)
• Flask
• Matplotlib
• Pickle

Launch a local instance of BiDRA

1. Clone this repo
2. Create a tmpdirectory to store data and figures
3. Within the stan repo, run compileStan.py to generate the compiled inference models
4. Launch the interface locally by running run.py