Mendelian Randomization Report: mtDNA-CN and MS Progression

This repository hosts the interactive HTML report accompanying the following peer-reviewed publication:

Sabaie H., Taghavi Rad A., et al.
Mitochondrial DNA Copy Number as a Hidden Player in the Progression of Multiple Sclerosis:
A Bidirectional Two-Sample Mendelian Randomization Study.
Molecular Neurobiology (2025)
DOI: https://doi.org/10.1007/s12035-025-04980-9

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🌐 Online HTML Report

The full interactive report is available at:

🔗 https://hani-sabaie.github.io/mtDNACN-MSP-MR/MR-Report.html

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📄 Repository Contents

• mtDNAcn_MS_prog.html
  Final rendered HTML report containing:
  • Bidirectional two-sample Mendelian randomization analyses
  • Sensitivity, pleiotropy, and directionality tests
  • Figures and summary tables referenced in the manuscript

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🔍 Purpose

This repository is provided to:

• Support transparency and reproducibility of the Mendelian randomization analyses
• Serve as a permanent, citable web-based supplement to the published article
• Enable interactive exploration of results beyond static figures

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🧪 Methods Summary

• Bidirectional two-sample Mendelian randomization
• GWAS summary statistics:
  • mtDNA copy number (UK Biobank; European ancestry)
  • Multiple sclerosis progression / severity (IMSGC; European ancestry)
• Primary estimator: inverse-variance weighted (IVW)
• Extensive sensitivity analyses:
  • MR-Egger, weighted median/mode
  • MR-PRESSO, RadialMR
  • MR-RAPS, MR-Lasso, MR-cML, dIVW, MBE
  • Steiger directionality tests

Full methodological details are described in the published article.

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⚠️ Notes

• Original GWAS data are publicly available from the respective resources/consortia.
• No individual-level data are included in this repository.