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4 changes: 3 additions & 1 deletion 01-intro2Genomics.Rmd
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Expand Up @@ -345,7 +345,7 @@ restricted to CpG dinucleotides, methylation can occur in other bases as well).
binding on the region, or methyl-CpG binding proteins induce the spread of
repressive chromatin domains, thus the gene is silenced if its promoter has
methylated CG dinucleotides. DNA methylation usually occurs in repeat
sequences to repress transposable elements. These elements, when active, can
sequences to repress transposable elements (Suggestion: DNA methylation usually occurs in repeat sequences, especially in transposable elements, to keep them inactive/repressed). These elements, when active, can
jump around and insert them to random parts of the genome, potentially disrupting
the genomic functions.\index{CpG island}

Expand Down Expand Up @@ -830,3 +830,5 @@ Consortium | What is it for?
\index{ENCODE}
\index{Epigenomics Roadmap}
\index{The Cancer Genome Atlas (TCGA)}