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Molecular complexity

Calculate molecular complexity from a V2000 Molfile.

Original column:
M. von Korff, T. Sander, Chimia, 2023, 77, 258, DOI: 10.2533/chimia.2023.258.

Original Java implementation:
github.com/Actelion/openchemlib

Note: Results may vary between the programs. This is most likely due to how chiral molecules are handled. May be fixed in the future?

Requirements

  • python (3.9.16 tested)
  • numpy (1.22.4 tested)
  • networkx (3.0 tested)

Usage

$ python complexity.py mols/alanine.mol
1.6309297535714573

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Calculate molecular complexity from a Molfile

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