A educational and gaming program to explore the role of two proteins in the parasitism of toxoplasmosis in humans.
Journal Citations
Besteiro S, Michelin A, Poncet J, Dubremetz JF, Lebrun M (2009) Export of a Toxoplasma gondii Rhoptry Neck Protein Complex at the Host Cell Membrane to Form the Moving Junction during Invasion. PLOS Pathogens 5(2): e1000309. https://doi.org/10.1371/journal.ppat.1000309
El Hajj H, Lebrun M, Arold ST, Vial H, Labesse G, et al. (2007) ROP18 Is a Rhoptry Kinase Controlling the Intracellular Proliferation of Toxoplasma gondii. PLOS Pathogens 3(2): e14. https://doi.org/10.1371/journal.ppat.0030014
Fentress, Sarah J., et al. "Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence." Cell host & microbe 8.6 (2010): 484-495.
Citation URL
Rop18 Model https://www.rcsb.org/pdb/ngl/ngl.do?pdbid=4JRN&bionumber=1
IRGa6 Model GTPasehttps://www.rcsb.org/pdb/explore/explore.do?structureId=5FPH
AMA-1 Model https://www.rcsb.org/pdb/explore/explore.do?structureId=2y8t
Cat Meow http://soundbible.com/1286-Kitten-meow.html
CDC Information https://www.cdc.gov/parasites/toxoplasmosis/index.html