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1. Resolve bugs for newer version of pandas.
2. Fix bug in low cell number regions.
3. Fix bug in DEobs self-defined background option.
4. Include genes in the transcriptome matrix but missing in the built-in annotation file.
1. Add self-defined background cells in fc.
2. Speed up global function.
3. Fix bug in the local function.
4. Improve performance of large datasets in DEobs and DErand.
1. Check fc query gene list first to avoid inconsistent gene
2. Add chrY genes in the annotation file
3. Model the background distribution as gamma distribution
4. Add up-regulation results of local function
5. Add manhattan function to generate Manhattan plots automatically
6. Add the self-defined background cells in the DEobs