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OptiWISE is a profiling tool providing granular Cycles per Instruction (CPI) and Instructions per Cycle (IPC) analysis of x86-64 and AArch64 Linux programs. It combines the information from two runs of the program: one using low-overhead sampling, and the other using high-overhead dynamic instrumentation. The results of these two runs are analyzed to give per instruction, per basic block, per loop, and per function overheads.