Scripts utilized in sudden cardiac death and proteomics association study in ARIC and CHS cohorts (manuscript in submission, citation to be updated).
1_Clean: filter SomaScan files received from ARIC-central and generate output for merging to SCD phenotype data for further exclusions in preparation for associations
2_Association: perform aptamer-SCD associations in ARIC
3_Meta: run meta-analysis of ARIC and CHS results, combine all meta-analyses into a single .rds file for downstream analyses, generate files used for manuscript figure and table creation. No stratified results were included in the manuscript (only combined meta-analysis using both races and sexes).
4_MR: format pQTL and SCD summary statistics then run MR
5_Risk.Score: protein-based risk score (PtRS) creation, using weights from ARIC-only data followed by leave-one-out cross-validation analysis in ARIC and assessing the clinical utility of the score
6_Manuscript: create figures and base .txt files for tables utilized in multi-panel figure