Codes and Scripts used for the paper 'Deleterious heteroplasmic mitochondrial mutations increase risk of overall and cancer-specific mortality'
medrxiv: https://www.medrxiv.org/content/10.1101/2022.09.20.22280151v1
MitoHPC: https://github.com/ArkingLab/MitoHPC
UKB_generatefiles.R: R codes for filtering raw heteroplasmic variants and generating useful files for downstream analysis
Data_cleaning: Rmd codes for filtering and organizing data for mortality analysis
circos_for_UKB.R: R codes for generating Figure 1
Data_analysis: Rmd codes for mortality analysis and generating Figure 2 to 7, Table 1 to 3
phewas.mtscore.R & phewas_functions.R: R codes for generating Figure 8a
ukb_heteroplasmy_phesant_heatmap.R: R codes for generating Figure 8b
Input: Input files used in this analysis
demo.rds: demo.rds file