If the header says something like:
Datetime:UTC,variable1
2001-01-01T00:00,1.2
2001-01-01T01:00,1.3
2001-01-01T02:00,43.4
...
Then
tstoolbox converttz EST America/New_York
should fail since "UTC" in the header doesn't match the fromtz value "EST" in the function call.