diff --git a/README.md b/README.md
index b4089086..2e35f860 100644
--- a/README.md
+++ b/README.md
@@ -4,6 +4,16 @@
 SolveBio Python Client
 ======================
 
+# This package is deprecated. Please install and use quartzbio instead:
+
+```bash
+pip install quartzbio
+```
+
+**This package will no longer be maintained after March 31, 2026.**
+
+**Migration guide: [https://github.com/quartzbio/quartzbio-python](https://github.com/quartzbio/quartzbio-python)**
+
 This is the SolveBio Python package and command-line interface (CLI).
 This module is tested against Python 2.7, 3.6, 3.7, 3.8, 3.10, PyPy and PyPy3.
 
diff --git a/setup.py b/setup.py
index 1664905b..cf5a9fed 100644
--- a/setup.py
+++ b/setup.py
@@ -55,7 +55,7 @@
 setup(
     name='solvebio',
     version=VERSION,
-    description='The SolveBio Python client',
+    description='The SolveBio Python client (DEPRECATED)',
     long_description=long_description,
     long_description_content_type='text/markdown',
     python_requires='>=3.8',
@@ -74,6 +74,7 @@
                             'solvebio-recipes = recipes.sync_recipes:sync_recipes']
     },
     classifiers=[
+        'Development Status :: 7 - Inactive',
         'Intended Audience :: Science/Research',
         'Operating System :: OS Independent',
         'Programming Language :: Python',
diff --git a/solvebio/__init__.py b/solvebio/__init__.py
index 460b3848..e36ddae0 100644
--- a/solvebio/__init__.py
+++ b/solvebio/__init__.py
@@ -13,6 +13,7 @@
 
 import os as _os
 import logging as _logging
+import warnings
 from typing import Literal
 from .help import open_help as _open_help
 
@@ -99,6 +100,45 @@ def _set_cached_api_host(host):
 
 from .version import VERSION  # noqa
 from .errors import SolveError
+
+
+_deprecation_warning_shown = False
+
+
+def print_deprecation_notice():
+    """
+    Shows the deprecation warning for the SolveBio Python client.
+    Only shows once per session to avoid repetition.
+    """
+    global _deprecation_warning_shown
+
+    if _deprecation_warning_shown:
+        return
+
+    _deprecation_warning_shown = True
+
+    message = """
+        !!! Deprecation Notice
+
+        The SolveBio Python client is deprecated and will no longer be maintained after March 31, 2026.
+
+        We recommend migrating to the QuartzBio python client:
+        https://github.com/quartzbio/quartzbio-python
+
+        """
+
+    if api_host is not None:
+        message += f"\nOr using the QuartzBio REST API: {api_host.replace('.api', '')}/swagger"
+
+    # Show warning and also print to ensure visibility
+    warnings.warn(
+        message,
+        DeprecationWarning,
+        stacklevel=2,
+    )
+    print(f"{message}")
+
+
 from .query import Query, BatchQuery, Filter, GenomicFilter
 from .global_search import GlobalSearch
 from .annotate import Annotator, Expression
@@ -176,6 +216,8 @@ def login(
         client.set_credentials(
             api_host, token, token_type=token_type, raise_on_missing=not debug, debug=debug
         )
+        # Show deprecation notice after credentials are set
+        print_deprecation_notice()
 
     client.set_user_agent(name=name, version=version)
 
diff --git a/solvebio/cli/auth.py b/solvebio/cli/auth.py
index ba147243..71ec310d 100644
--- a/solvebio/cli/auth.py
+++ b/solvebio/cli/auth.py
@@ -27,6 +27,7 @@ def login_and_save_credentials(*args):
     # Print information about the current user
     if not client.is_logged_in():
         print("login: client is not logged in!")
+        solvebio.print_deprecation_notice()
 
         # Verify if user has provided the wrong credentials file
         if client._host:
@@ -56,9 +57,10 @@ def logout(*args):
     """
     if get_credentials():
         delete_credentials()
-        print('You have been logged out.')
+        print("You have been logged out.")
     else:
-        print('You are not logged-in.')
+        print("You are not logged-in.")
+    solvebio.print_deprecation_notice()
 
 
 def whoami(*args, **kwargs):
@@ -69,7 +71,7 @@ def whoami(*args, **kwargs):
     try:
         user = client.whoami()
     except Exception as e:
-        print(u'{} (code: {})'.format(e.message, e.status_code))
+        print("{} (code: {})".format(e.message, e.status_code))
     else:
         print_user(user)
 
@@ -78,7 +80,9 @@ def print_user(user):
     """
     Prints information about the current user.
     """
-    email = user['email']
-    domain = user['account']['domain']
-    print(f'You are logged-in to the "{domain}" domain as {email}'
-          f' (server: {solvebio.get_api_host()}).')
+    email = user["email"]
+    domain = user["account"]["domain"]
+    print(
+        f'You are logged-in to the "{domain}" domain as {email}'
+        f" (server: {solvebio.get_api_host()})."
+    )
diff --git a/solvebio/cli/ipython_init.py b/solvebio/cli/ipython_init.py
index 5e1eba24..bde3eb85 100644
--- a/solvebio/cli/ipython_init.py
+++ b/solvebio/cli/ipython_init.py
@@ -32,6 +32,7 @@
 from solvebio import DatasetSnapshotTask  # noqa
 from solvebio import GlobalSearch  # noqa
 from solvebio import Group  # noqa
+from solvebio import print_deprecation_notice  # noqa
 from solvebio.utils.printing import pager  # noqa
 
 # Add some convenience functions to the interactive shell
@@ -39,4 +40,6 @@
 from solvebio.cli.auth import whoami  # noqa
 from solvebio.cli.auth import get_credentials  # noqa
 
+# Show deprecation notice when starting IPython shell
+print_deprecation_notice()
 whoami()