diff --git a/resources/python/bin/3.10/explicit_requirements.txt b/resources/python/bin/3.10/explicit_requirements.txt
index 4af52fd98..08d3d3b2e 100644
--- a/resources/python/bin/3.10/explicit_requirements.txt
+++ b/resources/python/bin/3.10/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==1.15.1
-cryptography==44.0.1
+cryptography==46.0.6
 zope.interface==5.5.2
diff --git a/resources/python/bin/3.11/explicit_requirements.txt b/resources/python/bin/3.11/explicit_requirements.txt
index 4af52fd98..08d3d3b2e 100644
--- a/resources/python/bin/3.11/explicit_requirements.txt
+++ b/resources/python/bin/3.11/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==1.15.1
-cryptography==44.0.1
+cryptography==46.0.6
 zope.interface==5.5.2
diff --git a/resources/python/bin/3.13/explicit_requirements.txt b/resources/python/bin/3.13/explicit_requirements.txt
index 001db32c4..d7e49abcb 100644
--- a/resources/python/bin/3.13/explicit_requirements.txt
+++ b/resources/python/bin/3.13/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==1.17.1
-cryptography==44.0.3
+cryptography==46.0.6
 zope.interface==7.1.1
diff --git a/resources/python/bin/3.7/explicit_requirements.txt b/resources/python/bin/3.7/explicit_requirements.txt
index 4af52fd98..08d3d3b2e 100644
--- a/resources/python/bin/3.7/explicit_requirements.txt
+++ b/resources/python/bin/3.7/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==1.15.1
-cryptography==44.0.1
+cryptography==46.0.6
 zope.interface==5.5.2
diff --git a/resources/python/bin/3.9/explicit_requirements.txt b/resources/python/bin/3.9/explicit_requirements.txt
index 4af52fd98..08d3d3b2e 100644
--- a/resources/python/bin/3.9/explicit_requirements.txt
+++ b/resources/python/bin/3.9/explicit_requirements.txt
@@ -9,5 +9,5 @@
 # agreement to the Shotgun Pipeline Toolkit Source Code License. All rights
 # not expressly granted therein are reserved by Shotgun Software Inc.
 cffi==1.15.1
-cryptography==44.0.1
+cryptography==46.0.6
 zope.interface==5.5.2