diff --git a/CPU_Mac_Requirements.txt b/CPU_Mac_Requirements.txt
index 2b3f3d1..6d945ee 100644
--- a/CPU_Mac_Requirements.txt
+++ b/CPU_Mac_Requirements.txt
@@ -103,7 +103,7 @@ scikit-learn==0.21.2
 scipy==1.3.0
 seaborn==0.9.0
 send2trash==1.5.0
-setuptools==41.0.1
+setuptools==65.5.1
 simpleitk==1.2.0
 simplejson==3.16.0
 sip==4.19.8