diff --git a/backends/xnnpack/runtime/XNNWeightsCache.cpp b/backends/xnnpack/runtime/XNNWeightsCache.cpp
index 54191b72825..303076460ed 100644
--- a/backends/xnnpack/runtime/XNNWeightsCache.cpp
+++ b/backends/xnnpack/runtime/XNNWeightsCache.cpp
@@ -208,6 +208,12 @@ size_t XNNWeightsCache::look_up_or_insert(
 
   if (offset != SIZE_MAX) {
     void* saved_ptr = context->offset_to_addr(context, offset);
+    // Check for null pointers before calling memcmp
+    if (ptr == nullptr || saved_ptr == nullptr) {
+      // If either pointer is null (due to deleted data or allocation failure), treat as cache miss
+      // and return SIZE_MAX to trigger reinsertion.
+      return SIZE_MAX;
+    }
     if (0 == memcmp(ptr, saved_ptr, size)) {
       return offset;
     }