diff --git a/.github/workflows/run-tests.yml b/.github/workflows/run-tests.yml
index 82bca72d7a..c9fd81005e 100644
--- a/.github/workflows/run-tests.yml
+++ b/.github/workflows/run-tests.yml
@@ -13,7 +13,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        python-version: ["3.9", "3.10", "3.11", "3.12", "3.13", "3.14", "3.15-dev", "pypy-3.11"]
+        python-version: ["3.10", "3.11", "3.12", "3.13", "3.14", "3.15-dev", "pypy-3.11"]
         os: [ubuntu-22.04, macOS-latest, windows-latest]
         # Pypy-3.11 can't install openssl-sys with rust
         # which prevents us from testing in GHA.
@@ -45,10 +45,10 @@ jobs:
 
     steps:
       - uses: actions/checkout@de0fac2e4500dabe0009e67214ff5f5447ce83dd
-      - name: 'Set up Python 3.9'
+      - name: 'Set up Python 3.10'
         uses: actions/setup-python@a309ff8b426b58ec0e2a45f0f869d46889d02405
         with:
-          python-version: '3.9'
+          python-version: '3.10'
       - name: Install dependencies
         run: |
           make
@@ -65,10 +65,10 @@ jobs:
 
     steps:
       - uses: actions/checkout@de0fac2e4500dabe0009e67214ff5f5447ce83dd
-      - name: 'Set up Python 3.9'
+      - name: 'Set up Python 3.10'
         uses: actions/setup-python@a309ff8b426b58ec0e2a45f0f869d46889d02405
         with:
-          python-version: '3.9'
+          python-version: '3.10'
       - name: Install dependencies
         run: |
           make
diff --git a/README.md b/README.md
index 74adab80dd..66640ff080 100644
--- a/README.md
+++ b/README.md
@@ -33,7 +33,7 @@ Requests is available on PyPI:
 $ python -m pip install requests
 ```
 
-Requests officially supports Python 3.9+.
+Requests officially supports Python 3.10+.
 
 ## Supported Features & Best–Practices
 
diff --git a/pyproject.toml b/pyproject.toml
index 8f4fe5bad6..f9513bf015 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -14,7 +14,7 @@ maintainers = [
     {name = "Ian Stapleton Cordasco", email="graffatcolmingov@gmail.com"},
     {name = "Nate Prewitt", email="nate.prewitt@gmail.com"}
 ]
-requires-python = ">=3.9"
+requires-python = ">=3.10"
 dependencies = [
     "charset_normalizer>=2,<4",
     "idna>=2.5,<4",
@@ -32,7 +32,6 @@ classifiers = [
     "Operating System :: OS Independent",
     "Programming Language :: Python",
     "Programming Language :: Python :: 3",
-    "Programming Language :: Python :: 3.9",
     "Programming Language :: Python :: 3.10",
     "Programming Language :: Python :: 3.11",
     "Programming Language :: Python :: 3.12",
@@ -85,8 +84,7 @@ select = [
     "UP",     # pyupgrade
     "T10",    # flake8-debugger (replaces debug-statements hook)
 ]
-# UP036: Remove once Python 3.10 is the minimum supported version
-ignore = ["E203", "E501", "UP038", "UP031", "UP036"]
+ignore = ["E203", "E501", "UP038", "UP031"]
 per-file-ignores = {"src/requests/__init__.py" = ["E402", "F401"], "src/requests/compat.py" = ["E402", "F401"], "tests/compat.py" = ["F401"]}
 
 [tool.ruff.lint.isort]
diff --git a/setup.py b/setup.py
index f5f816ae67..1095518ac8 100755
--- a/setup.py
+++ b/setup.py
@@ -1,7 +1,7 @@
 import sys
 
-if sys.version_info < (3, 9):
-    sys.stderr.write("Requests requires Python 3.9 or later.\n")
+if sys.version_info < (3, 10):  # noqa: UP036
+    sys.stderr.write("Requests requires Python 3.10 or later.\n")
     sys.exit(1)
 
 from setuptools import setup
diff --git a/tox.ini b/tox.ini
index 70c2855123..b316359aae 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,5 @@
 [tox]
-envlist = py{39,310,311,312,313,314}-{default, use_chardet_on_py3}
+envlist = py{310,311,312,313,314}-{default, use_chardet_on_py3}
 
 [testenv]
 deps = -rrequirements-dev.txt