diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index eeeee439f..7b63f5a0f 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -13,6 +13,7 @@ repos:
     hooks:
       - id: check-merge-conflict
       - id: debug-statements
+        exclude: ^(src/click/testing\.py|tests/test_testing\.py)$
       - id: fix-byte-order-marker
       - id: trailing-whitespace
       - id: end-of-file-fixer
diff --git a/src/click/testing.py b/src/click/testing.py
index ebfd54dc7..fe079ba8f 100644
--- a/src/click/testing.py
+++ b/src/click/testing.py
@@ -4,6 +4,7 @@
 import contextlib
 import io
 import os
+import pdb
 import shlex
 import sys
 import tempfile
@@ -390,12 +391,55 @@ def should_strip_ansi(
         old__getchar_func = termui._getchar
         old_should_strip_ansi = utils.should_strip_ansi  # type: ignore
         old__compat_should_strip_ansi = _compat.should_strip_ansi
+        old_pdb_init = pdb.Pdb.__init__
         termui.visible_prompt_func = visible_input
         termui.hidden_prompt_func = hidden_input
         termui._getchar = _getchar
         utils.should_strip_ansi = should_strip_ansi  # type: ignore
         _compat.should_strip_ansi = should_strip_ansi
 
+        def _patched_pdb_init(
+            self: pdb.Pdb,
+            completekey: str = "tab",
+            stdin: t.IO[str] | None = None,
+            stdout: t.IO[str] | None = None,
+            **kwargs: t.Any,
+        ) -> None:
+            """Default ``pdb.Pdb`` to real terminal streams during
+            ``CliRunner`` isolation.
+
+            Without this patch, ``pdb.Pdb.__init__`` inherits from
+            ``cmd.Cmd`` which falls back to ``sys.stdin``/``sys.stdout``
+            when no explicit streams are provided. During isolation
+            those are ``BytesIO``-backed wrappers, so the debugger
+            reads from an empty buffer and writes to captured output,
+            making interactive debugging impossible.
+
+            By defaulting to ``sys.__stdin__``/``sys.__stdout__`` (the
+            original terminal streams Python preserves regardless of
+            redirection), debuggers can interact with the user while
+            ``click.echo`` output is still captured normally.
+
+            This covers ``pdb.set_trace()``, ``breakpoint()``,
+            ``pdb.post_mortem()``, and debuggers that subclass
+            ``pdb.Pdb`` (ipdb, pdbpp). Explicit ``stdin``/``stdout``
+            arguments are honored and not overridden. Debuggers that
+            do not subclass ``pdb.Pdb`` (pudb, debugpy) are not
+            covered.
+
+            See: https://github.com/pallets/click/issues/654 and
+            https://github.com/pallets/click/issues/824
+            """
+            if stdin is None:
+                stdin = sys.__stdin__
+            if stdout is None:
+                stdout = sys.__stdout__
+            old_pdb_init(
+                self, completekey=completekey, stdin=stdin, stdout=stdout, **kwargs
+            )
+
+        pdb.Pdb.__init__ = _patched_pdb_init  # type: ignore[assignment]
+
         old_env = {}
         try:
             for key, value in env.items():
@@ -426,6 +470,7 @@ def should_strip_ansi(
             utils.should_strip_ansi = old_should_strip_ansi  # type: ignore
             _compat.should_strip_ansi = old__compat_should_strip_ansi
             formatting.FORCED_WIDTH = old_forced_width
+            pdb.Pdb.__init__ = old_pdb_init  # type: ignore[method-assign]
 
     def invoke(
         self,
diff --git a/tests/test_testing.py b/tests/test_testing.py
index 11fe29dc5..47144716c 100644
--- a/tests/test_testing.py
+++ b/tests/test_testing.py
@@ -1,4 +1,5 @@
 import os
+import pdb
 import sys
 from io import BytesIO
 
@@ -469,3 +470,52 @@ def cli():
 
     result = runner.invoke(cli)
     assert result.stderr == "gyarados gyarados gyarados"
+
+
+def test_pdb_uses_real_streams():
+    """``pdb.Pdb()`` inside ``CliRunner`` defaults to real terminal streams
+    so that interactive debuggers work instead of reading from the
+    captured ``BytesIO`` stdin.
+    """
+
+    @click.command()
+    def cli():
+        debugger = pdb.Pdb()
+        assert debugger.stdin is sys.__stdin__
+        assert debugger.stdout is sys.__stdout__
+        click.echo("after debugger")
+
+    runner = CliRunner()
+    result = runner.invoke(cli, catch_exceptions=False)
+    assert result.output == "after debugger\n"
+
+
+def test_pdb_explicit_streams_honored():
+    """Explicit ``stdin``/``stdout`` arguments to ``pdb.Pdb()`` are not
+    overridden by the ``CliRunner`` patch.
+    """
+
+    @click.command()
+    def cli():
+        custom_in = sys.stdin
+        custom_out = sys.stdout
+        debugger = pdb.Pdb(stdin=custom_in, stdout=custom_out)
+        assert debugger.stdin is custom_in
+        assert debugger.stdout is custom_out
+
+    runner = CliRunner()
+    runner.invoke(cli, catch_exceptions=False)
+
+
+def test_pdb_init_restored_after_invoke():
+    """``pdb.Pdb.__init__`` is restored to its original after invoke."""
+    original = pdb.Pdb.__init__
+
+    @click.command()
+    def cli():
+        pass
+
+    runner = CliRunner()
+    runner.invoke(cli)
+
+    assert pdb.Pdb.__init__ is original