diff --git a/.github/workflows/test-shared.yml b/.github/workflows/test-shared.yml
index 07b87270106373..8723392bf96489 100644
--- a/.github/workflows/test-shared.yml
+++ b/.github/workflows/test-shared.yml
@@ -192,7 +192,7 @@ jobs:
             --arg ccache '(import <nixpkgs> {}).sccache' \
             --arg devTools '[]' \
             --arg benchmarkTools '[]' \
-            ${{ endsWith(matrix.system, '-darwin') && '--arg extraConfigFlags ''["--without-amaro" "--without-inspector"]'' \' || '\' }}
+            ${{ endsWith(matrix.system, '-darwin') && '--arg extraConfigFlags ''["--without-amaro" "--without-inspector" "--without-node-options"]'' \' || '\' }}
             --run '
                 make -C "$TAR_DIR" run-ci -j4 V=1 TEST_CI_ARGS="-p actions --measure-flakiness 9 --skip-tests=$CI_SKIP_TESTS"
             '
diff --git a/test/embedding/test-embedding.js b/test/embedding/test-embedding.js
index 71c4f7f324c973..49706079fd8b6a 100644
--- a/test/embedding/test-embedding.js
+++ b/test/embedding/test-embedding.js
@@ -154,7 +154,7 @@ for (const extraSnapshotArgs of [
 }
 
 // Guarantee NODE_REPL_EXTERNAL_MODULE won't bypass kDisableNodeOptionsEnv
-{
+if (!process.config.variables.node_without_node_options) {
   spawnSyncAndExit(
     binary,
     ['require("os")'],
diff --git a/test/es-module/test-esm-import-flag.mjs b/test/es-module/test-esm-import-flag.mjs
index 81de3b11a38609..c0c22704f53a8a 100644
--- a/test/es-module/test-esm-import-flag.mjs
+++ b/test/es-module/test-esm-import-flag.mjs
@@ -9,6 +9,7 @@ const cjsImport = fixtures.fileURL('es-modules', 'cjs-file.cjs');
 const mjsEntry = fixtures.path('es-modules', 'mjs-file.mjs');
 const mjsImport = fixtures.fileURL('es-modules', 'mjs-file.mjs');
 
+const onlyIfNodeOptionsSupport = { skip: process.config.variables.node_without_node_options };
 
 describe('import modules using --import', { concurrency: !process.env.TEST_PARALLEL }, () => {
   it('should import when using --eval', async () => {
@@ -199,7 +200,7 @@ describe('import modules using --import', { concurrency: !process.env.TEST_PARAL
     assert.strictEqual(signal, null);
   });
 
-  it('should import files from the env before ones from the CLI', async () => {
+  it('should import files from the env before ones from the CLI', onlyIfNodeOptionsSupport, async () => {
     const { code, signal, stderr, stdout } = await spawnPromisified(
       execPath,
       [
diff --git a/test/es-module/test-esm-symlink-type.js b/test/es-module/test-esm-symlink-type.js
index 76f03d4f46d457..29819b0b5ecca2 100644
--- a/test/es-module/test-esm-symlink-type.js
+++ b/test/es-module/test-esm-symlink-type.js
@@ -6,6 +6,10 @@ const assert = require('assert');
 const exec = require('child_process').execFile;
 const fs = require('fs');
 
+if (process.config.variables.node_without_node_options) {
+  common.skip('missing NODE_OPTIONS support');
+}
+
 const tmpdir = require('../common/tmpdir');
 tmpdir.refresh();
 const tmpDir = tmpdir.path;
diff --git a/test/es-module/test-esm-type-field-errors.js b/test/es-module/test-esm-type-field-errors.js
index 4bf52f3ad6e7d3..dcd411202068b5 100644
--- a/test/es-module/test-esm-type-field-errors.js
+++ b/test/es-module/test-esm-type-field-errors.js
@@ -4,6 +4,10 @@ const assert = require('assert');
 const exec = require('child_process').execFile;
 const { describe, it } = require('node:test');
 
+if (process.config.variables.node_without_node_options) {
+  common.skip('missing NODE_OPTIONS support');
+}
+
 const mjsFile = require.resolve('../fixtures/es-modules/mjs-file.mjs');
 const cjsFile = require.resolve('../fixtures/es-modules/cjs-file.cjs');
 const packageWithoutTypeMain =
diff --git a/test/parallel/test-cli-options-as-flags.js b/test/parallel/test-cli-options-as-flags.js
index 04e9e801b8ec81..403a18d162ca61 100644
--- a/test/parallel/test-cli-options-as-flags.js
+++ b/test/parallel/test-cli-options-as-flags.js
@@ -12,6 +12,8 @@ const fixtureFile = fixtures.path(path.join('options-as-flags', 'fixture.cjs'));
 const configFile = fixtures.path(path.join('options-as-flags', 'test-config.json'));
 const envFile = fixtures.path(path.join('options-as-flags', '.test.env'));
 
+const onlyIfNodeOptionsSupport = { skip: process.config.variables.node_without_node_options };
+
 describe('getOptionsAsFlagsFromBinding', () => {
   it('should extract flags from command line arguments', async () => {
     const result = await spawnPromisified(process.execPath, [
@@ -28,7 +30,7 @@ describe('getOptionsAsFlagsFromBinding', () => {
     assert.strictEqual(flags.includes('--stack-trace-limit=512'), true);
   });
 
-  it('should extract flags from NODE_OPTIONS environment variable', async () => {
+  it('should extract flags from NODE_OPTIONS environment variable', onlyIfNodeOptionsSupport, async () => {
     const result = await spawnPromisified(process.execPath, [
       '--no-warnings',
       '--expose-internals',
@@ -49,7 +51,7 @@ describe('getOptionsAsFlagsFromBinding', () => {
     assert.strictEqual(flags.includes('--no-warnings'), true);
   });
 
-  it('should extract flags from config file', async () => {
+  it('should extract flags from config file', onlyIfNodeOptionsSupport, async () => {
     const result = await spawnPromisified(process.execPath, [
       '--no-warnings',
       '--expose-internals',
@@ -69,7 +71,7 @@ describe('getOptionsAsFlagsFromBinding', () => {
     assert.strictEqual(flags.includes('--no-warnings'), true);
   });
 
-  it('should extract flags from config file and command line', async () => {
+  it('should extract flags from config file and command line', onlyIfNodeOptionsSupport, async () => {
     const result = await spawnPromisified(process.execPath, [
       '--no-warnings',
       '--expose-internals',
@@ -92,7 +94,7 @@ describe('getOptionsAsFlagsFromBinding', () => {
     assert.strictEqual(flags.includes('--test-isolation=none'), true);
   });
 
-  it('should extract flags from .env file', async () => {
+  it('should extract flags from .env file', onlyIfNodeOptionsSupport, async () => {
     const result = await spawnPromisified(process.execPath, [
       '--no-warnings',
       '--expose-internals',
diff --git a/test/parallel/test-config-file.js b/test/parallel/test-config-file.js
index 9ffc2a90bee9e1..c18cc0d45683b6 100644
--- a/test/parallel/test-config-file.js
+++ b/test/parallel/test-config-file.js
@@ -13,7 +13,14 @@ const { test, it, describe } = require('node:test');
 const { chmodSync, writeFileSync, constants } = require('node:fs');
 const { join } = require('node:path');
 
+const onlyIfNodeOptionsSupport = { skip: process.config.variables.node_without_node_options };
 const onlyWithAmaro = { skip: !process.config.variables.node_use_amaro };
+const onlyWithAmaroAndNodeOptions = {
+  skip: !process.config.variables.node_use_amaro || process.config.variables.node_without_node_options,
+};
+const onlyWithInspectorAndNodeOptions = {
+  skip: !process.features.inspector || process.config.variables.node_without_node_options,
+};
 
 test('should handle non existing json', async () => {
   const result = await spawnPromisified(process.execPath, [
@@ -51,7 +58,7 @@ test('should handle empty object json', async () => {
   assert.strictEqual(result.code, 0);
 });
 
-test('should parse boolean flag', onlyWithAmaro, async () => {
+test('should parse boolean flag', onlyWithAmaroAndNodeOptions, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--experimental-config-file',
     fixtures.path('rc/transform-types.json'),
@@ -62,7 +69,7 @@ test('should parse boolean flag', onlyWithAmaro, async () => {
   assert.strictEqual(result.code, 0);
 });
 
-test('should parse boolean flag defaulted to true', async () => {
+test('should parse boolean flag defaulted to true', onlyIfNodeOptionsSupport, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--experimental-config-file',
     fixtures.path('rc/warnings-false.json'),
@@ -85,7 +92,7 @@ test('should throw an error when a flag is declared twice', async () => {
   assert.strictEqual(result.code, 9);
 });
 
-test('should override env-file', onlyWithAmaro, async () => {
+test('should override env-file', onlyWithAmaroAndNodeOptions, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--experimental-config-file',
@@ -128,7 +135,7 @@ test('should not override CLI flags', onlyWithAmaro, async () => {
   assert.strictEqual(result.code, 1);
 });
 
-test('should parse array flag correctly', async () => {
+test('should parse array flag correctly', onlyIfNodeOptionsSupport, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--experimental-config-file',
@@ -152,7 +159,7 @@ test('should validate invalid array flag', async () => {
   assert.strictEqual(result.code, 9);
 });
 
-test('should validate array flag as string', async () => {
+test('should validate array flag as string', onlyIfNodeOptionsSupport, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--experimental-config-file',
@@ -188,7 +195,7 @@ test('should throw at flag not available in NODE_OPTIONS', async () => {
   assert.strictEqual(result.code, 9);
 });
 
-test('unsigned flag should be parsed correctly', async () => {
+test('unsigned flag should be parsed correctly', onlyIfNodeOptionsSupport, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--experimental-config-file',
@@ -225,7 +232,7 @@ test('v8 flag should not be allowed in config file', async () => {
   assert.strictEqual(result.code, 9);
 });
 
-test('string flag should be parsed correctly', async () => {
+test('string flag should be parsed correctly', onlyIfNodeOptionsSupport, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--test',
@@ -238,7 +245,7 @@ test('string flag should be parsed correctly', async () => {
   assert.strictEqual(result.code, 0);
 });
 
-test('host port flag should be parsed correctly', { skip: !process.features.inspector }, async () => {
+test('host port flag should be parsed correctly', onlyWithInspectorAndNodeOptions, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--expose-internals',
@@ -251,7 +258,7 @@ test('host port flag should be parsed correctly', { skip: !process.features.insp
   assert.strictEqual(result.code, 0);
 });
 
-test('--inspect=true should be parsed correctly', { skip: !process.features.inspector }, async () => {
+test('--inspect=true should be parsed correctly', onlyWithInspectorAndNodeOptions, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--experimental-config-file',
@@ -351,7 +358,7 @@ test('broken value in node_options', async () => {
   assert.strictEqual(result.code, 9);
 });
 
-test('should use node.config.json as default', async () => {
+test('should use node.config.json as default', onlyIfNodeOptionsSupport, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--experimental-default-config-file',
@@ -364,7 +371,7 @@ test('should use node.config.json as default', async () => {
   assert.strictEqual(result.code, 0);
 });
 
-test('should override node.config.json when specificied', async () => {
+test('should override node.config.json when specificied', onlyIfNodeOptionsSupport, async () => {
   const result = await spawnPromisified(process.execPath, [
     '--no-warnings',
     '--experimental-default-config-file',
diff --git a/test/parallel/test-max-old-space-size-percentage.js b/test/parallel/test-max-old-space-size-percentage.js
index c5071d2f959ce3..88db60299e1526 100644
--- a/test/parallel/test-max-old-space-size-percentage.js
+++ b/test/parallel/test-max-old-space-size-percentage.js
@@ -44,6 +44,10 @@ invalidPercentages.forEach((input) => {
   assert.match(result.stderr.toString(), input[1]);
 });
 
+if (process.config.variables.node_without_node_options) {
+  common.skip('missing NODE_OPTIONS support');
+}
+
 // Test NODE_OPTIONS with valid percentages
 validPercentages.forEach((input) => {
   const result = spawnSync(process.execPath, [], {
diff --git a/test/parallel/test-permission-allow-child-process-cli.js b/test/parallel/test-permission-allow-child-process-cli.js
index f2ec02f02f46f5..d82332ba3d5084 100644
--- a/test/parallel/test-permission-allow-child-process-cli.js
+++ b/test/parallel/test-permission-allow-child-process-cli.js
@@ -8,6 +8,9 @@ const { isMainThread } = require('worker_threads');
 if (!isMainThread) {
   common.skip('This test only works on a main thread');
 }
+if (process.config.variables.node_without_node_options) {
+  common.skip('missing NODE_OPTIONS support');
+}
 
 const assert = require('assert');
 const childProcess = require('child_process');
diff --git a/test/parallel/test-permission-child-process-inherit-flags.js b/test/parallel/test-permission-child-process-inherit-flags.js
index fb1506bf274f43..36e89bfb1c7286 100644
--- a/test/parallel/test-permission-child-process-inherit-flags.js
+++ b/test/parallel/test-permission-child-process-inherit-flags.js
@@ -7,6 +7,9 @@ const { isMainThread } = require('worker_threads');
 if (!isMainThread) {
   common.skip('This test only works on a main thread');
 }
+if (process.config.variables.node_without_node_options) {
+  common.skip('missing NODE_OPTIONS support');
+}
 
 const assert = require('assert');
 const childProcess = require('child_process');
diff --git a/test/parallel/test-process-warnings.mjs b/test/parallel/test-process-warnings.mjs
index 907681b25c4630..75e4986b817dc1 100644
--- a/test/parallel/test-process-warnings.mjs
+++ b/test/parallel/test-process-warnings.mjs
@@ -9,6 +9,8 @@ const dep1Message = /\(node:\d+\) \[DEP1\] DeprecationWarning/;
 const dep2Message = /\(node:\d+\) \[DEP2\] DeprecationWarning/;
 const experimentalWarningMessage = /\(node:\d+\) ExperimentalWarning/;
 
+const onlyIfNodeOptionsSupport = { skip: process.config.variables.node_without_node_options };
+
 describe('process warnings', { concurrency: !process.env.TEST_PARALLEL }, () => {
 
   it('should emit all warnings by default', async () => {
@@ -142,7 +144,7 @@ describe('process warnings', { concurrency: !process.env.TEST_PARALLEL }, () =>
       assert.strictEqual(signal, null);
     });
 
-    it('should be specifiable in NODE_OPTIONS', async () => {
+    it('should be specifiable in NODE_OPTIONS', onlyIfNodeOptionsSupport, async () => {
       const { stdout, stderr, code, signal } = await spawnPromisified(process.execPath, [
         fixturePath,
       ], {
diff --git a/test/parallel/test-unicode-node-options.js b/test/parallel/test-unicode-node-options.js
index e5a40d118791d3..3f8cf46d986cd3 100644
--- a/test/parallel/test-unicode-node-options.js
+++ b/test/parallel/test-unicode-node-options.js
@@ -1,10 +1,14 @@
 'use strict';
 // Flags: --expose-internals
-require('../common');
+const common = require('../common');
 const { getOptionValue } = require('internal/options');
 const assert = require('assert');
 const cp = require('child_process');
 
+if (process.config.variables.node_without_node_options) {
+  common.skip('missing NODE_OPTIONS support');
+}
+
 const expected_redirect_value = 'foó';
 
 if (process.argv.length === 2) {
diff --git a/test/parallel/test-worker-execargv-invalid.js b/test/parallel/test-worker-execargv-invalid.js
index be8ab0b8c423b7..06c33c678dbcb3 100644
--- a/test/parallel/test-worker-execargv-invalid.js
+++ b/test/parallel/test-worker-execargv-invalid.js
@@ -1,9 +1,13 @@
 'use strict';
 
-require('../common');
+const common = require('../common');
 const assert = require('assert');
 const { Worker } = require('worker_threads');
 
+if (process.config.variables.node_without_node_options) {
+  common.skip('missing NODE_OPTIONS support');
+}
+
 {
   const expectedErr = {
     code: 'ERR_INVALID_ARG_TYPE',
diff --git a/test/parallel/test-worker-node-options.js b/test/parallel/test-worker-node-options.js
index 7a26154e2f4800..73f71b57ac7607 100644
--- a/test/parallel/test-worker-node-options.js
+++ b/test/parallel/test-worker-node-options.js
@@ -1,10 +1,15 @@
 'use strict';
 
-require('../common');
+const common = require('../common');
 const {
   spawnSyncAndExitWithoutError,
   spawnSyncAndAssert,
 } = require('../common/child_process');
+
+if (process.config.variables.node_without_node_options) {
+  common.skip('missing NODE_OPTIONS support');
+}
+
 const fixtures = require('../common/fixtures');
 spawnSyncAndExitWithoutError(
   process.execPath,