diff --git a/modules/nf-core/savana/run/environment.yml b/modules/nf-core/savana/run/environment.yml
new file mode 100644
index 00000000000..60063b5bf6b
--- /dev/null
+++ b/modules/nf-core/savana/run/environment.yml
@@ -0,0 +1,7 @@
+---
+# yaml-language-server: $schema=https://raw.githubusercontent.com/nf-core/modules/master/modules/environment-schema.json
+channels:
+  - conda-forge
+  - bioconda
+dependencies:
+  - "bioconda::savana=1.3.7"
diff --git a/modules/nf-core/savana/run/main.nf b/modules/nf-core/savana/run/main.nf
new file mode 100644
index 00000000000..ff55160da49
--- /dev/null
+++ b/modules/nf-core/savana/run/main.nf
@@ -0,0 +1,50 @@
+process SAVANA_RUN {
+    tag "${meta.id}"
+    label 'process_high'
+
+    conda "${moduleDir}/environment.yml"
+    container "${workflow.containerEngine in ['singularity', 'apptainer'] && !task.ext.singularity_pull_docker_container
+        ? 'https://depot.galaxyproject.org/singularity/savana:1.3.7--pyhdfd78af_0'
+        : 'quay.io/biocontainers/savana:1.3.7--pyhdfd78af_0'}"
+
+    input:
+    tuple val(meta), path(tumour), path(tumour_index), path(normal), path(normal_index)
+    tuple val(meta2),path(ref), path(ref_index)
+
+    output:
+    tuple val(meta), path("${prefix}.sv_breakpoints.vcf"), emit: sv_breakpoints_vcf
+    tuple val(meta), path("${prefix}.sv_breakpoints.bedpe"), emit: sv_breakpoints_bedpe
+    tuple val(meta), path("${prefix}.sv_breakpoints_read_support.tsv"), emit: sv_breakpoints_read_support
+    tuple val(meta), path("${prefix}.inserted_sequences.fa"), emit: inserted_sequences
+    tuple val("${task.process}"), val("savana"), eval("python -c \"import importlib.metadata as m; print(m.version('savana'))\""), emit: versions_savana, topic: versions
+
+    when:
+    task.ext.when == null || task.ext.when
+
+    script:
+    def args = (task.ext.args ?: '').trim()
+    prefix = task.ext.prefix ?: "${meta.id}"
+    def outdir = "."
+    """
+    savana run \\
+        --tumour ${tumour} \\
+        --normal ${normal} \\
+        --ref ${ref} \\
+        --ref_index ${ref_index} \\
+        --outdir ${outdir} \\
+        --sample ${prefix} \\
+        --threads ${task.cpus ?: 1} \\
+        ${args}
+    """
+
+    stub:
+    prefix = task.ext.prefix ?: "${meta.id}"
+    def outdir = "."
+    """
+    mkdir -p ${outdir}
+    touch ${outdir}/${prefix}.sv_breakpoints.vcf
+    touch ${outdir}/${prefix}.sv_breakpoints.bedpe
+    touch ${outdir}/${prefix}.sv_breakpoints_read_support.tsv
+    touch ${outdir}/${prefix}.inserted_sequences.fa
+    """
+}
diff --git a/modules/nf-core/savana/run/meta.yml b/modules/nf-core/savana/run/meta.yml
new file mode 100644
index 00000000000..4061b89912d
--- /dev/null
+++ b/modules/nf-core/savana/run/meta.yml
@@ -0,0 +1,130 @@
+name: "savana_run"
+description: "Identify and cluster SV breakpoints from long-read alignments."
+keywords:
+  - structural variants
+  - long read
+  - genomics
+tools:
+  - "savana":
+      description: "SAVANA: a somatic structural variant and copy-number caller for
+        long-read data."
+      homepage: "https://github.com/cortes-ciriano-lab/savana"
+      documentation: "https://github.com/cortes-ciriano-lab/savana"
+      tool_dev_url: "https://github.com/cortes-ciriano-lab/savana"
+      doi: "10.1038/s41592-025-02708-0"
+      licence:
+        - "Apache-2.0"
+      identifier: ""
+input:
+  - - meta:
+        type: map
+        description: |
+          Groovy Map containing sample information
+          e.g. `[ id:'sample1' ]`
+    - tumour:
+        type: file
+        description: Tumour BAM/CRAM file
+        pattern: "*.{bam,cram}"
+        ontologies:
+          - edam: "http://edamontology.org/format_2572" # BAM
+          - edam: "http://edamontology.org/format_3462" # CRAM
+    - tumour_index:
+        type: file
+        description: Tumour BAM/CRAM index
+        pattern: "*.{bai,crai}"
+        ontologies: []
+    - normal:
+        type: file
+        description: Normal BAM/CRAM file
+        pattern: "*.{bam,cram}"
+        ontologies:
+          - edam: "http://edamontology.org/format_2572" # BAM
+          - edam: "http://edamontology.org/format_3462" # CRAM
+    - normal_index:
+        type: file
+        description: Normal BAM/CRAM index
+        pattern: "*.{bai,crai}"
+        ontologies: []
+  - - meta2:
+        type: map
+        description: |
+          Groovy Map containing reference information
+          e.g. `[ id:'hg38' ]`
+    - ref:
+        type: file
+        description: Reference genome FASTA file used to align tumor and normal
+          BAM/CRAM files
+        pattern: "*.{fa,fasta}"
+        ontologies:
+          - edam: "http://edamontology.org/format_1929" # FASTA
+    - ref_index:
+        type: file
+        description: Reference FASTA index
+        pattern: "*.fai"
+        ontologies: []
+output:
+  sv_breakpoints_vcf:
+    - - meta:
+          type: map
+          description: Sample information
+      - ${prefix}.sv_breakpoints.vcf:
+          type: file
+          description: VCF file containing raw SV breakpoints
+          pattern: "*.sv_breakpoints.vcf"
+          ontologies:
+            - edam: "http://edamontology.org/format_3016"
+  sv_breakpoints_bedpe:
+    - - meta:
+          type: map
+          description: Sample information
+      - ${prefix}.sv_breakpoints.bedpe:
+          type: file
+          description: BEDPE file containing SV breakpoints
+          pattern: "*.sv_breakpoints.bedpe"
+          ontologies:
+            - edam: "http://edamontology.org/format_3003" # BED
+  sv_breakpoints_read_support:
+    - - meta:
+          type: map
+          description: Sample information
+      - ${prefix}.sv_breakpoints_read_support.tsv:
+          type: file
+          description: TSV file containing read support information for each SV breakpoint
+          pattern: "*.sv_breakpoints_read_support.tsv"
+          ontologies:
+            - edam: "http://edamontology.org/format_3475" # TSV
+  inserted_sequences:
+    - - meta:
+          type: map
+          description: Sample information
+      - ${prefix}.inserted_sequences.fa:
+          type: file
+          description: FASTA file containing inserted sequences
+          pattern: "*.inserted_sequences.fa"
+          ontologies:
+            - edam: "http://edamontology.org/format_1929" # FASTA
+  versions_savana:
+    - - ${task.process}:
+          type: string
+          description: Process name
+      - savana:
+          type: string
+          description: Tool version
+      - python -c "import importlib.metadata as m; print(m.version('savana'))":
+          type: eval
+          description: Command to obtain the version of the tool
+topics:
+  versions:
+    - - ${task.process}:
+          type: string
+          description: Process name
+      - savana:
+          type: string
+          description: Tool version
+      - python -c "import importlib.metadata as m; print(m.version('savana'))":
+          type: eval
+          description: Command to obtain the version of the tool
+authors:
+  - "@manascripts"
+maintainers:
+  - "@manascripts"
diff --git a/modules/nf-core/savana/run/tests/main.nf.test b/modules/nf-core/savana/run/tests/main.nf.test
new file mode 100644
index 00000000000..f397e17585c
--- /dev/null
+++ b/modules/nf-core/savana/run/tests/main.nf.test
@@ -0,0 +1,113 @@
+nextflow_process {
+
+    name "Test Process SAVANA_RUN"
+    script "../main.nf"
+    process "SAVANA_RUN"
+
+    tag "modules"
+    tag "modules_nfcore"
+    tag "savana"
+    tag "savana/run"
+
+    test("homo_sapiens - nanopore") {
+
+        when {
+            process {
+                """
+                input[0] = [
+                    [ id:'test' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/nanopore/bam/test2.sorted.bam', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/nanopore/bam/test2.sorted.bam.bai', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/nanopore/bam/test.sorted.phased.bam', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/nanopore/bam/test.sorted.phased.bam.bai', checkIfExists: true)
+                ]
+
+                input[1] = [
+                    [ id:'ref' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/genome/genome.fasta', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/genome/genome.fasta.fai', checkIfExists: true)
+                ]
+                """
+            }
+        }
+
+        then {
+            assertAll(
+                { assert process.success },
+                { assert snapshot(
+                    path(process.out.sv_breakpoints_vcf.get(0).get(1)).vcf.summary,
+                    file(process.out.sv_breakpoints_bedpe.get(0).get(1)).name,
+                    file(process.out.sv_breakpoints_read_support.get(0).get(1)).readLines().size(),
+                    file(process.out.inserted_sequences.get(0).get(1)).name,
+                    process.out.findAll { key, val -> key.startsWith('versions') }
+                ).match() }
+            )
+        }
+    }
+
+    test("homo_sapiens - pacbio") {
+
+        when {
+            process {
+                """
+                input[0] = [
+                    [ id:'test' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/pacbio/bam/test.sorted.bam', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/pacbio/bam/test.sorted.bam.bai', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/pacbio/bam/test_hifi_aligned_to_assembly.bam', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/pacbio/bam/test_hifi_aligned_to_assembly.bam.bai', checkIfExists: true)
+                ]
+
+                input[1] = [
+                    [ id:'ref' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/genome/genome.fasta', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/genome/genome.fasta.fai', checkIfExists: true)
+                ]
+                """
+            }
+        }
+
+        then {
+            assertAll(
+                { assert process.success },
+                { assert snapshot(
+                    path(process.out.sv_breakpoints_vcf.get(0).get(1)).vcf.summary,
+                    file(process.out.sv_breakpoints_bedpe.get(0).get(1)).name,
+                    file(process.out.sv_breakpoints_read_support.get(0).get(1)).readLines().size(),
+                    file(process.out.inserted_sequences.get(0).get(1)).name,
+                    process.out.findAll { key, val -> key.startsWith('versions') }
+                ).match() }
+            )
+        }
+    }
+
+    test("homo_sapiens - nanopore - stub") {
+
+        options "-stub"
+
+        when {
+            process {
+                """
+                input[0] = [
+                    [ id:'test' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/nanopore/bam/test2.sorted.bam', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/nanopore/bam/test2.sorted.bam.bai', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/nanopore/bam/test.sorted.phased.bam', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/nanopore/bam/test.sorted.phased.bam.bai', checkIfExists: true)
+                ]
+
+                input[1] = [
+                    [ id:'ref' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/genome/genome.fasta', checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/genome/genome.fasta.fai', checkIfExists: true)
+                ]
+                """
+            }
+        }
+
+        then {
+            assert process.success
+            assert snapshot(sanitizeOutput(process.out)).match()
+        }
+    }
+}
diff --git a/modules/nf-core/savana/run/tests/main.nf.test.snap b/modules/nf-core/savana/run/tests/main.nf.test.snap
new file mode 100644
index 00000000000..3e5563f05bc
--- /dev/null
+++ b/modules/nf-core/savana/run/tests/main.nf.test.snap
@@ -0,0 +1,96 @@
+{
+    "homo_sapiens - pacbio": {
+        "content": [
+            "VcfFile [chromosomes=[], sampleCount=1, variantCount=0, phased=true, phasedAutodetect=true]",
+            "test.sv_breakpoints.bedpe",
+            1,
+            "test.inserted_sequences.fa",
+            {
+                "versions_savana": [
+                    [
+                        "SAVANA_RUN",
+                        "savana",
+                        "1.3.7"
+                    ]
+                ]
+            }
+        ],
+        "timestamp": "2026-05-15T14:24:46.790612822",
+        "meta": {
+            "nf-test": "0.9.5",
+            "nextflow": "25.10.4"
+        }
+    },
+    "homo_sapiens - nanopore": {
+        "content": [
+            "VcfFile [chromosomes=[chr22], sampleCount=1, variantCount=28, phased=false, phasedAutodetect=false]",
+            "test.sv_breakpoints.bedpe",
+            16,
+            "test.inserted_sequences.fa",
+            {
+                "versions_savana": [
+                    [
+                        "SAVANA_RUN",
+                        "savana",
+                        "1.3.7"
+                    ]
+                ]
+            }
+        ],
+        "timestamp": "2026-05-15T14:24:30.660792995",
+        "meta": {
+            "nf-test": "0.9.5",
+            "nextflow": "25.10.4"
+        }
+    },
+    "homo_sapiens - nanopore - stub": {
+        "content": [
+            {
+                "inserted_sequences": [
+                    [
+                        {
+                            "id": "test"
+                        },
+                        "test.inserted_sequences.fa:md5,d41d8cd98f00b204e9800998ecf8427e"
+                    ]
+                ],
+                "sv_breakpoints_bedpe": [
+                    [
+                        {
+                            "id": "test"
+                        },
+                        "test.sv_breakpoints.bedpe:md5,d41d8cd98f00b204e9800998ecf8427e"
+                    ]
+                ],
+                "sv_breakpoints_read_support": [
+                    [
+                        {
+                            "id": "test"
+                        },
+                        "test.sv_breakpoints_read_support.tsv:md5,d41d8cd98f00b204e9800998ecf8427e"
+                    ]
+                ],
+                "sv_breakpoints_vcf": [
+                    [
+                        {
+                            "id": "test"
+                        },
+                        "test.sv_breakpoints.vcf:md5,d41d8cd98f00b204e9800998ecf8427e"
+                    ]
+                ],
+                "versions_savana": [
+                    [
+                        "SAVANA_RUN",
+                        "savana",
+                        "1.3.7"
+                    ]
+                ]
+            }
+        ],
+        "timestamp": "2026-05-15T14:24:57.388853983",
+        "meta": {
+            "nf-test": "0.9.5",
+            "nextflow": "25.10.4"
+        }
+    }
+}
\ No newline at end of file