diff --git a/modules/nf-core/civicpy/annotate/environment.yml b/modules/nf-core/civicpy/annotate/environment.yml
new file mode 100644
index 00000000000..44d06b899ca
--- /dev/null
+++ b/modules/nf-core/civicpy/annotate/environment.yml
@@ -0,0 +1,8 @@
+---
+# yaml-language-server: $schema=https://raw.githubusercontent.com/nf-core/modules/master/modules/environment-schema.json
+channels:
+  - conda-forge
+  - bioconda
+  - nodefaults
+dependencies:
+  - "bioconda::civicpy=5.2.0"
diff --git a/modules/nf-core/civicpy/annotate/main.nf b/modules/nf-core/civicpy/annotate/main.nf
new file mode 100644
index 00000000000..4574e80c127
--- /dev/null
+++ b/modules/nf-core/civicpy/annotate/main.nf
@@ -0,0 +1,42 @@
+process CIVICPY_ANNOTATE {
+    tag "${meta.id}"
+    label 'process_single'
+
+    conda "${moduleDir}/environment.yml"
+    container "${workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container
+        ? 'https://depot.galaxyproject.org/singularity/civicpy:5.2.0--pyhdfd78af_0'
+        : 'docker.io/griffithlab/civicpy:v5.2.0' }"
+
+    input:
+    tuple val(meta), path(vcf), path(tbi)
+    val annotation_genome_version
+
+    output:
+    tuple val(meta), path("*.vcf"),                                                                                   emit: vcf
+    tuple val("${task.process}"), val('civicpy'), eval("civicpy --version | sed 's/.*version //'"), topic: versions, emit: versions_civicpy
+
+    when:
+    task.ext.when == null || task.ext.when
+
+    script:
+    def args   = task.ext.args   ?: ''
+    def prefix = task.ext.prefix ?: "${meta.id}.civic"
+
+    """
+    export CIVICPY_CACHE_FILE=\$PWD/.civicpy
+
+    civicpy annotate-vcf \\
+        --input-vcf ${vcf} \\
+        --output-vcf ${prefix}.vcf \\
+        --reference ${annotation_genome_version} \\
+        ${args}
+    """
+
+    stub:
+    def args   = task.ext.args   ?: ''
+    def prefix = task.ext.prefix ?: "${meta.id}.civic"
+
+    """
+    touch ${prefix}.vcf
+    """
+}
diff --git a/modules/nf-core/civicpy/annotate/meta.yml b/modules/nf-core/civicpy/annotate/meta.yml
new file mode 100644
index 00000000000..8ab945fcbf7
--- /dev/null
+++ b/modules/nf-core/civicpy/annotate/meta.yml
@@ -0,0 +1,69 @@
+---
+# yaml-language-server: $schema=https://raw.githubusercontent.com/nf-core/modules/master/modules/meta-schema.json
+name: "civicpy_annotate"
+
+description: A python client and analysis toolkit for the Clinical Interpretations of Variants in Cancer (CIViC) knowledgebase
+keywords:
+  - clinical interpretation
+  - variant annotation
+  - genetic variation analysis
+  - genomics
+tools:
+  - "civicpy":
+      description: "CIViC variant knowledgebase analysis toolkit."
+      homepage: "https://docs.civicpy.org/en/latest/"
+      documentation: "https://docs.civicpy.org/en/latest/"
+      tool_dev_url: "https://github.com/griffithlab/civicpy"
+      doi: "10.1200/CCI.19.00127"
+      licence: ["MIT"]
+      identifier: biotools:CIViCpy
+
+input:
+  - - meta:
+        type: map
+        description: |
+          Groovy Map containing sample information
+          e.g. `[ id:'sample1', single_end:false ]`
+
+    - vcf:
+        type: file
+        description: Sorted and indexed VCF file
+        pattern: "*.{vcf}"
+        ontologies:
+          - edam: "http://edamontology.org/format_3016"
+
+    - tbi:
+        type: file
+        description: Tabix index for the input VCF
+        pattern: "*.tbi"
+
+  - annotation_genome_version:
+      type: string
+      description: Reference genome version passed to civicpy (e.g. GRCh38)
+
+output:
+  vcf:
+    - - meta:
+          type: map
+          description: |
+            Groovy Map containing sample information
+            e.g. `[ id:'sample1', single_end:false ]`
+      - "*.vcf":
+          type: file
+          description: Annotated VCF file
+          pattern: "*.vcf"
+          ontologies:
+            - edam: "http://edamontology.org/format_3016"
+
+  versions:
+    - versions.yml:
+        type: file
+        description: File containing software versions
+        pattern: "versions.yml"
+        ontologies:
+          - edam: http://edamontology.org/format_3750 # YAML
+
+authors:
+  - "@emmcauley"
+maintainers:
+  - "@emmcauley"
diff --git a/modules/nf-core/civicpy/annotate/tests/main.nf.test b/modules/nf-core/civicpy/annotate/tests/main.nf.test
new file mode 100644
index 00000000000..8ddac86b877
--- /dev/null
+++ b/modules/nf-core/civicpy/annotate/tests/main.nf.test
@@ -0,0 +1,95 @@
+nextflow_process {
+
+    name "Test Process CIVICPY_ANNOTATE"
+    script "../main.nf"
+    process "CIVICPY_ANNOTATE"
+    config "./nextflow.config"
+    tag "modules"
+    tag "modules_nfcore"
+    tag "civicpy"
+    tag "civicpy/annotate"
+
+    test("homo_sapiens - vcf - GRCh38") {
+
+        when {
+            process {
+                """
+                input[0] = [
+                    [ id:'test_sample' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/illumina/gatk/paired_mutect2_calls/test_test2_paired_mutect2_calls.vcf.gz',    checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/illumina/gatk/paired_mutect2_calls/test_test2_paired_mutect2_calls.vcf.gz.tbi', checkIfExists: true)
+                ]
+                input[1] = 'GRCh38'
+                """
+            }
+        }
+
+        then {
+            assertAll(
+                { assert process.success },
+                { assert snapshot(
+                    path(process.out.vcf[0][1]).vcf.variantsMD5,
+                    process.out.versions_civicpy
+                ).match() }
+            )
+        }
+
+    }
+
+    test("homo_sapiens - vcf - GRCh37") {
+
+        when {
+            process {
+                """
+                input[0] = [
+                    [ id:'test_sample' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/illumina/gatk/paired_mutect2_calls/test_test2_paired_mutect2_calls.vcf.gz',    checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/illumina/gatk/paired_mutect2_calls/test_test2_paired_mutect2_calls.vcf.gz.tbi', checkIfExists: true)
+                ]
+                input[1] = 'GRCh37'
+                """
+            }
+        }
+
+        then {
+            assertAll(
+                { assert process.success },
+                { assert snapshot(
+                    path(process.out.vcf[0][1]).vcf.variantsMD5,
+                    process.out.versions_civicpy
+                ).match() }
+            )
+        }
+
+    }
+
+    test("homo_sapiens - vcf - GRCh38 - stub") {
+
+        options "-stub"
+
+        when {
+            process {
+                """
+                input[0] = [
+                    [ id:'test_sample' ],
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/illumina/gatk/paired_mutect2_calls/test_test2_paired_mutect2_calls.vcf.gz',    checkIfExists: true),
+                    file(params.modules_testdata_base_path + 'genomics/homo_sapiens/illumina/gatk/paired_mutect2_calls/test_test2_paired_mutect2_calls.vcf.gz.tbi', checkIfExists: true)
+                ]
+                input[1] = 'GRCh38'
+                """
+            }
+        }
+
+        then {
+            assertAll(
+                { assert process.success },
+                { assert snapshot(
+                    file(process.out.vcf[0][1]).name,
+                    process.out.versions_civicpy
+                ).match() }
+            )
+        }
+
+    }
+
+}
diff --git a/modules/nf-core/civicpy/annotate/tests/main.nf.test.snap b/modules/nf-core/civicpy/annotate/tests/main.nf.test.snap
new file mode 100644
index 00000000000..55afc1df116
--- /dev/null
+++ b/modules/nf-core/civicpy/annotate/tests/main.nf.test.snap
@@ -0,0 +1,53 @@
+{
+    "homo_sapiens - vcf - GRCh38 - stub": {
+        "content": [
+            "test_sample.civic.vcf",
+            [
+                [
+                    "CIVICPY_ANNOTATE",
+                    "civicpy",
+                    "5.2.0"
+                ]
+            ]
+        ],
+        "meta": {
+            "nf-test": "0.9.3",
+            "nextflow": "25.10.2"
+        },
+        "timestamp": "2026-03-26T17:38:23.86228"
+    },
+    "homo_sapiens - vcf - GRCh37": {
+        "content": [
+            "bf3fe04101ac5b192de625ebf9a4324f",
+            [
+                [
+                    "CIVICPY_ANNOTATE",
+                    "civicpy",
+                    "5.2.0"
+                ]
+            ]
+        ],
+        "meta": {
+            "nf-test": "0.9.3",
+            "nextflow": "25.10.2"
+        },
+        "timestamp": "2026-03-27T11:16:21.699688"
+    },
+    "homo_sapiens - vcf - GRCh38": {
+        "content": [
+            "bf3fe04101ac5b192de625ebf9a4324f",
+            [
+                [
+                    "CIVICPY_ANNOTATE",
+                    "civicpy",
+                    "5.2.0"
+                ]
+            ]
+        ],
+        "meta": {
+            "nf-test": "0.9.3",
+            "nextflow": "25.10.2"
+        },
+        "timestamp": "2026-03-27T11:15:57.673023"
+    }
+}
\ No newline at end of file
diff --git a/modules/nf-core/civicpy/annotate/tests/nextflow.config b/modules/nf-core/civicpy/annotate/tests/nextflow.config
new file mode 100644
index 00000000000..6822afe82b3
--- /dev/null
+++ b/modules/nf-core/civicpy/annotate/tests/nextflow.config
@@ -0,0 +1,5 @@
+process {
+    withName: CIVICPY_ANNOTATE {
+        ext.args = '--include-status accepted'
+    }
+}