diff --git a/variants/xiao_nrf52/platformio.ini b/variants/xiao_nrf52/platformio.ini
index a085433688..af248c594b 100644
--- a/variants/xiao_nrf52/platformio.ini
+++ b/variants/xiao_nrf52/platformio.ini
@@ -26,8 +26,11 @@ build_flags = ${nrf52_base.build_flags}
   -D SX126X_DIO3_TCXO_VOLTAGE=1.8
   -D SX126X_CURRENT_LIMIT=140
   -D SX126X_RX_BOOSTED_GAIN=1
-  -D PIN_WIRE_SCL=D6
-  -D PIN_WIRE_SDA=D7
+  ; D6/D7 are also defined as PIN_SERIAL1_TX/RX in variant.h. Muxing Wire
+  ; there causes BLE/USB instability after init on the Wio-SX1262 for XIAO
+  ; baseboard. Use the NFC pads (P0.30 NFC1, P0.31 NFC2) instead.
+  -D PIN_WIRE_SDA=30
+  -D PIN_WIRE_SCL=31
   -D PIN_USER_BTN=PIN_BUTTON1
   -D DISPLAY_CLASS=NullDisplayDriver
 build_src_filter = ${nrf52_base.build_src_filter}