-
Notifications
You must be signed in to change notification settings - Fork 0
Expand file tree
/
Copy pathindex.html
More file actions
355 lines (345 loc) · 16.7 KB
/
index.html
File metadata and controls
355 lines (345 loc) · 16.7 KB
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8">
<meta name="viewport" content="width=device-width, initial-scale=1">
<title>Manish Datt</title>
<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/bulma@0.9.4/css/bulma.min.css">
<link rel="preconnect" href="https://fonts.googleapis.com">
<link rel="preconnect" href="https://fonts.gstatic.com" crossorigin>
<link href="https://fonts.googleapis.com/css2?family=Geo&family=Lato&family=Bungee+Shade&display=swap" rel="stylesheet">
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome-animation/0.3.0/font-awesome-animation.min.css">
<script src="https://kit.fontawesome.com/c6d49cdb5e.js" crossorigin="anonymous"></script>
</head>
<body>
<section class="has-background-grey-dark">
<!-- <p class="is-size-6 has-text-right has-text-white pr-4">
Research Contact</p>
--> <br>
</section>
<section class="section pt-5 px-6 pb-0 has-background-grey-dark">
<div class="columns is-centered" style="min-height: 30vh;">
<div class="column is-three-fifths title is-size-3 is-size-4-mobile has-text-weight-normal">
<span lang="hi" class="has-text-white ">
कर्मण्येवाधिकारस्ते मा फलेषु कदाचन। <br>
मा कर्मफलहेतुर्भूर्मा ते सङ्गोऽस्त्वकर्मणि॥
<p class="subtitle is-size-6 has-text-right mt-2 has-text-white pr-6">
भगवद गीता २-४७</p>
</span>
<p class="is-size-6 mt-1 has-text-grey-light translation" style="margin-left: -1em;"><u>Translate</u></p>
<div class="column is-hidden" id="trans_eng" style="margin-left: -1em; margin-top: -0.25em;">
<span class="is-size-6 has-text-light">
<p>You have the right to work only but never to its fruits.</p>
<p>Let not the fruits of action be your motive,
nor let your attachment be to inaction.</p>
<p class="has-text-right pr-5"><small>Bhagwad Gita, Chapter 2, Verse 47</small></p>
</span>
</div>
</div>
</div>
</section>
<section class="section py-5">
<div class="column is-four-fifths is-offset-1 is-full-mobile">
<div class="tabs is-boxed is-medium is-small-mobile is-centered">
<ul>
<li class="is-active" data-target="Welcome">
<a>
<span class="icon"><i class="fa-solid fa-hands-praying" aria-hidden="true"></i></span>
<span>Welcome</span>
</a>
</li>
<li data-target="Education">
<a>
<span class="icon"><i class="fas fa-building-columns" aria-hidden="true"></i></span>
<span>Education</span>
</a>
</li>
<li data-target="Experience">
<a>
<span class="icon"><i class="fas fa-user-tie" aria-hidden="true"></i></span>
<span>Experience</span>
</a>
</li>
<li data-target="Fellowships">
<a>
<span class="icon"><i class="fas fa-graduation-cap" aria-hidden="true"></i></span>
<span>Fellowships</span>
</a>
</li>
</ul>
</div>
<div class="px-1" id="tab-content" style="min-height: 250px;">
<div class="columns" id="Welcome">
<div class="column is-one-third has-text-centered">
<figure class="is-inline-block">
<img src="images/MD_headshot_grey.jpg" alt="Manish Datt"
style="object-fit: cover; border-radius: 50%; width: 200px; height: 200px;
box-shadow: 0px 10px 20px grey;">
</figure>
</div>
<div class="column is-full">
<p class="title is-size-5 mb-6 pt-2">
Three things you should know about me
</p>
<div class="subtitle mb-4" style="list-style-type: none;">
<p class="mb-4"><span class="is-size-4" style="font-family: Bungee Shade; font-weight: bold;">1 </span>
I enjoy data science and its application in biology.</p>
<p class="mb-4"><span class="is-size-4" style="font-family: Bungee Shade; font-weight: bold;">2 </span>
I am intrigued by the structure and dynamics of biomolecules.</p>
<p class="mb-6"><span class="is-size-4" style="font-family: Bungee Shade; font-weight: bold;">3 </span>
I strive to foster knowledge-sharing, which keeps me motivated.</p>
</div>
</div>
</div>
<div id="Education" class="columns is-hidden">
<div class="column is-one-third has-text-centered">
<figure class="is-inline-block">
<img src="images/MD_headshot_grey.jpg" alt="Manish Datt"
style="object-fit: cover; border-radius: 50%; width: 200px; height: 200px;
box-shadow: 0px 10px 20px grey;">
</figure>
</div>
<div class="column is-full">
<p class="title is-size-5">
PhD – Bioinformatics – 2004-2010
</p>
<p class="subtitle mb-6">
CSIR-Institute of Microbial Technology, Chandigarh, India.
</p>
<p class="title is-size-5">
MSc – Biotechnology – 2002-2004
</p>
<p class="subtitle mb-6">
Panjab University, Chandigarh, India.
</p>
<p class="title is-size-5">
BSc – Biochemistry – 1998-2001
</p>
<p class="subtitle mb-4">
University of Delhi, New Delhi, India.
</p>
</div>
</div>
<div id="Experience" class="columns is-hidden">
<div class="column is-one-third has-text-centered">
<figure class="is-inline-block">
<img src="images/MD_headshot_grey.jpg" alt="Manish Datt"
style="object-fit: cover; border-radius: 50%; width: 200px; height: 200px;
box-shadow: 0px 10px 20px grey;">
</figure>
</div>
<div class="column is-four-fifths">
<p class="title is-size-5 mb-4">
Associate Professor – 2022-2023
</p>
<p class="subtitle is-size-6 mb-5">
MIT World Peace University, Maharashtra, India.
</p>
<p class="title is-size-5 mb-4 mt-1">
Assistant Professor – 2015-2021
</p>
<p class="subtitle is-size-6 mb-5">
Ahmedabad University, Gujarat, India.
</p>
<p class="title is-size-5 mb-4 mt-1">
Research Scientist – 2012-2015
</p>
<p class="subtitle is-size-6 mb-5">
International Center for Genetic Engineering and Biotechnology, New Delhi, India.
</p>
<p class="title is-size-5 mb-4">
Post-doctoral Scholar – 2010-2012
</p>
<p class="subtitle is-size-6 mb-1">
Case Western Reserve University, OH, USA.
</p>
</div>
</div>
<div id="Fellowships" class="columns is-hidden">
<div class="column is-one-third has-text-centered">
<figure class="is-inline-block">
<img src="images/MD_headshot_grey.jpg" alt="Manish Datt"
style="object-fit: cover; border-radius: 50%; width: 200px; height: 200px;
box-shadow: 0px 10px 20px grey;">
</figure>
</div>
<div class="column is-full">
<p class="title is-size-5">
The Argosy Fellow – 2017
</p>
<p class="subtitle mb-6">
Olin College of Engineering, MA, USA.
</p>
<p class="title is-size-5">
Senior Research Fellow – 2006-2009
</p>
<p class="subtitle mb-6">
Council of Scientific and Industrial Research, India.
</p>
<p class="title is-size-5">
Junior Research Fellow – 2004-2006
</p>
<p class="subtitle mb-6">
Council of Scientific and Industrial Research, India.
</p>
</div>
</div>
</div>
</div>
</section>
<div class="column is-four-fifths is-offset-1 is-full-mobile mb-5"
style="margin-top: -4em;">
<p class="subtitle is-size-5 box">I am the founder of <a href="https://bioinfo.guru"><span style="font-family: Geo; color: #9c51e0; font-size: 125%;">bioinfo.guru</span></a> — a digital-first learning
platform that aims to empower biologists by helping them apply
computational methods in their research.
</p>
<p class="subtitle is-size-5 box">I blog at <a href="https://my.bioinfo.guru">
<span style="font-family: Geo; color: #9c51e0; font-size: 125%;">my.bioinfo.guru</span></a>
about coding, biology, and everything in-between. <br>
Check out my books on <a href="https://pythonbook.bioinfo.guru">Python</a> and <a href="https://rbook.bioinfo.guru">R</a>,
and my data visualization <a href="https://dataviz.manishdatt.com">notebooks</a>.
</p>
</div>
<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/bulma-carousel@4.0.3/dist/css/bulma-carousel.min.css">
<section class="column is-four-fifths is-offset-1 is-full-mobile">
<p class="title is-size-5">Research highlights
(<a href="https://pubmed.ncbi.nlm.nih.gov/?term=manish+datt%5BAuthor%5D&sort=" target="_blank">PubMed</a>)</p>
<div class="container" style="overflow: hidden;">
<!-- Start Carousel -->
<div id="carousel-demo" class="carousel">
<div class="item-1">
<div class="card">
<div class="card-image">
<figure class="image is-3by1 is-covered">
<img
src="images/Fig_FEL.png"
alt="Free energy landscape" style="object-fit: scale-down;"
/>
</figure>
</div>
<div class="card-content">
<p>Aminoacyl-tRNA synthetases are an indispensable component
of ribosomal protein translational machinery and have been
validated as a potential drug target for malaria. The dynamic
conformational landscape of <i>Plasmodium</i> tyrosyl-tRNA
synthetase has been analyzed in the presence and absence
of bound ligand. All-atom simulations with a cumulative time
scale of microseconds show quantitative differences in the
conformational diversity of this enzyme.</p>
<p><b>Datt M*</b></p>
<p>Interplay of substrate polymorphism and conformational plasticity of <i>Plasmodium</i> tyrosyl-tRNA synthetase.
Computational Biology and Chemistry, Vol. 95, Dec 2021.</p>
</div>
</div>
</div>
<div class="item-2">
<div class="card">
<div class="card-image">
<figure class="image is-3by1 is-covered">
<img
src="images/3Biotech_docking.jpg"
alt="Free energy landscape" style="object-fit: scale-down;"
/>
</figure>
</div>
<div class="card-content">
<p>We have explored the prospects of repositioning the
repertoire of approved drugs and natural products for
potentially inhibiting malarial protein translation
machinery. Molecular docking of a diverse set of small
molecules with lysyl-, prolyl-, and tyrosyl- synthetases
from <i>Plasmodium</i> and human helped us identify promising
lead molecules. Overall, this study provides an exciting
foundation for the development of specific antimalarials.
</p>
<p>Doshi K, Pandya N, <b>Datt M*</b>.</p>
<p>In silico assessment of natural products and approved drugs as potential inhibitory scaffolds targeting aminoacyl-tRNA synthetases from <i>Plasmodium</i>.
3 Biotech. 2020 Nov;10(11):470.
</p>
</div>
</div>
</div>
<div class="item-3">
<div class="card">
<div class="card-image">
<figure class="image is-3by1 is-covered">
<img
src="images/Geometric_analysis.jpg"
alt="Convex hull" style="object-fit: scale-down;"
/>
</figure>
</div>
<div class="card-content">
<p>Understanding a protein structure is indispensable to decipher
the molecular underpinning of its physiological functions. Protein
structure is a collection of Cartesian coordinates of atoms
within the covalently connected amino-acids.
Iterative calculation of convex hull layers in the
structures have provided interesting insights into the
packing of atoms in the proteins. The figure shows
coordinates of C-alpha atoms of a protein structure (left)
and the right image shows the same set of coordinates colored
according to different convex hull layers.
<p><b>Datt M*</b></p>
<p>Geometric analysis of the conformational features of protein structures (BIOMAT 2015)</p>
</div>
</div>
</div>
<div class="item-4">
<div class="card">
<div class="card-image">
<figure class="image is-3by1 is-covered">
<img
src="images/NP_violin.png"
alt="Natural products" style="object-fit: scale-down;"
/>
</figure>
</div>
<div class="card-content">
<p>Natural Products (NPs) are chemical compounds that exist
within the living systems. These molecules are suitable
candidates for lead discovery. Molecular descriptor
based evaluation of chemical space for NPs has provided
interesting insights into their drug-likeliness. A
detailed comparison of NPs from two different databases
and FDA-approved drugs highlight the potential for NPs
as lead molecules. The figure shows the distribution of
molecules based on quantitative estimation of
drug-likeness (QED) in two NP databases and their
comparison with approved drugs.
</p>
<p><b>Datt M*</b> and Shah H</p>
<p>Molecular Descriptor Based Evaluation of Drug-Likeliness
and Chemical Space of Natural Products.</p>
</div>
</div>
</div>
</div>
<!-- End Carousel -->
</div>
</section>
<script src="https://cdn.jsdelivr.net/npm/bulma-carousel@4.0.4/dist/js/bulma-carousel.min.js"></script>
<script>
bulmaCarousel.attach('#carousel-demo', {
slidesToScroll: 1,
slidesToShow: 1,
pagination: false,
infinite: true,
});
</script>
<div class="footer has-background-grey-dark has-text-light has-text-centered">
<span class="icon is-size-5">
<a class="has-text-link-light" href="https://in.linkedin.com/in/manishdatt">
<i class="fa-brands fa-linkedin-in"></i></a>
<a class="has-text-link-light" href="https://twitter.com/dr_manishdatt">
<i class="fa-brands fa-x-twitter"></i></a>
<a class="has-text-link-light" href="https://bsky.app/profile/manishdatt.com">
<i class="fa-brands fa-bluesky"></i></a>
</span>
<p>bioinfo<span class="icon is-size-6 has-text-light"><i class="fas fa-at"></i></span>manishdatt.com</p>
</div>
<script src="index.js"></script>
</body>
</html>