diff --git a/scripts/populate_tox/tox.jinja b/scripts/populate_tox/tox.jinja
index 79d8659f37..b4b487a008 100644
--- a/scripts/populate_tox/tox.jinja
+++ b/scripts/populate_tox/tox.jinja
@@ -185,6 +185,7 @@ setenv =
     PYTHONDONTWRITEBYTECODE=1
     OBJC_DISABLE_INITIALIZE_FORK_SAFETY=YES
     COVERAGE_FILE=.coverage-sentry-{envname}
+    UV_CACHE_DIR={env:HOME}/.cache/uv/{envname}
 
     UV_PRERELEASE=if-necessary-or-explicit
     {% for group, integrations in groups.items() %}
diff --git a/tox.ini b/tox.ini
index 7374816f05..2f5bb808b8 100644
--- a/tox.ini
+++ b/tox.ini
@@ -13644,6 +13644,7 @@ setenv =
     PYTHONDONTWRITEBYTECODE=1
     OBJC_DISABLE_INITIALIZE_FORK_SAFETY=YES
     COVERAGE_FILE=.coverage-sentry-{envname}
+    UV_CACHE_DIR={env:HOME}/.cache/uv/{envname}
 
     UV_PRERELEASE=if-necessary-or-explicit
     pydantic_ai-v2.0.0b5: UV_PRERELEASE=allow