diff --git a/index.js b/index.js
index 7be5933..12b5fcd 100644
--- a/index.js
+++ b/index.js
@@ -604,8 +604,10 @@ async function fastifyHttpProxy (fastify, opts) {
         rewritePrefixWithVariables = rewritePrefixWithVariables.replace(`:${name}`, value)
       }
 
-      dest = dest.replace(prefixPathWithVariables, rewritePrefixWithVariables)
-    } else {
+      if (dest.startsWith(prefixPathWithVariables)) {
+        dest = dest.replace(prefixPathWithVariables, rewritePrefixWithVariables)
+      }
+    } else if (dest.startsWith(prefix)) {
       dest = dest.replace(prefix, rewritePrefix)
     }
 
diff --git a/test/test.js b/test/test.js
index 7996dad..da7bfac 100644
--- a/test/test.js
+++ b/test/test.js
@@ -925,6 +925,27 @@ async function run () {
     t.assert.strictEqual(fromParametersUrl, '/api2/echo-query?foo=bar&baz=qux')
   })
 
+  test('fromParameters should only rewrite a leading non-parameterized prefix', async t => {
+    let fromParametersUrl
+    const server = Fastify()
+    server.register(proxy, {
+      upstream: `http://localhost:${origin.server.address().port}`,
+      prefix: '/api',
+      rewritePrefix: '/api2',
+      preHandler (request, reply, done) {
+        const { url } = reply.fromParameters('/foo/api/bar', request.params, '/api')
+        fromParametersUrl = url
+        done()
+      }
+    })
+
+    await server.listen({ port: 0 })
+    t.after(() => server.close())
+
+    await fetch(`http://localhost:${server.server.address().port}/api/a`)
+    t.assert.strictEqual(fromParametersUrl, '/foo/api/bar')
+  })
+
   test('preRewrite handler', async t => {
     const proxyServer = Fastify()