diff --git a/compiler/packages/eslint-plugin-react-compiler/src/shared/RunReactCompiler.ts b/compiler/packages/eslint-plugin-react-compiler/src/shared/RunReactCompiler.ts
index aa55c64237e1..6afd18bdc5af 100644
--- a/compiler/packages/eslint-plugin-react-compiler/src/shared/RunReactCompiler.ts
+++ b/compiler/packages/eslint-plugin-react-compiler/src/shared/RunReactCompiler.ts
@@ -38,6 +38,8 @@ const COMPILER_OPTIONS: PluginOptions = {
     validateNoCapitalizedCalls: [],
     validateHooksUsage: true,
     validateNoDerivedComputationsInEffects: true,
+    // Keep this explicit so eslint behavior does not depend on compiler defaults.
+    enableAllowSetStateFromRefsInEffects: true,
   }),
 };
 
diff --git a/packages/eslint-plugin-react-hooks/__tests__/ReactCompilerRuleTypescript-test.ts b/packages/eslint-plugin-react-hooks/__tests__/ReactCompilerRuleTypescript-test.ts
index a0d0f6bdbc8e..6429d91c11e7 100644
--- a/packages/eslint-plugin-react-hooks/__tests__/ReactCompilerRuleTypescript-test.ts
+++ b/packages/eslint-plugin-react-hooks/__tests__/ReactCompilerRuleTypescript-test.ts
@@ -195,7 +195,62 @@ const tests: CompilerTestCases = {
   ],
 };
 
+const setStateInEffectTests: CompilerTestCases = {
+  valid: [
+    {
+      name: 'Allows setState in ref-guarded first render branch',
+      filename: 'test.tsx',
+      code: normalizeIndent`
+        import {useEffect, useRef, useState} from 'react';
+
+        function App() {
+          const isFirstRender = useRef(true);
+          const [stateValue, setStateValue] = useState(false);
+
+          useEffect(() => {
+            if (isFirstRender.current == true) {
+              isFirstRender.current = false;
+              setStateValue(true);
+            }
+          }, []);
+
+          return stateValue ? null : null;
+        }
+      `,
+    },
+  ],
+  invalid: [
+    {
+      name: 'Still reports synchronous setState in effect body',
+      filename: 'test.tsx',
+      code: normalizeIndent`
+        import {useEffect, useState} from 'react';
+
+        function App() {
+          const [stateValue, setStateValue] = useState(false);
+
+          useEffect(() => {
+            setStateValue(true);
+          }, []);
+
+          return stateValue ? null : null;
+        }
+      `,
+      errors: [
+        {
+          message: /Calling setState synchronously within an effect/,
+        },
+      ],
+    },
+  ],
+};
+
 const eslintTester = new ESLintTesterV8({
   parser: require.resolve('@typescript-eslint/parser-v5'),
 });
 eslintTester.run('react-compiler', allRules['immutability'].rule, tests);
+eslintTester.run(
+  'react-compiler set-state-in-effect',
+  allRules['set-state-in-effect'].rule,
+  setStateInEffectTests,
+);
diff --git a/packages/eslint-plugin-react-hooks/src/shared/RunReactCompiler.ts b/packages/eslint-plugin-react-hooks/src/shared/RunReactCompiler.ts
index 9aaddb07e656..bfc11b13b065 100644
--- a/packages/eslint-plugin-react-hooks/src/shared/RunReactCompiler.ts
+++ b/packages/eslint-plugin-react-hooks/src/shared/RunReactCompiler.ts
@@ -138,6 +138,8 @@ const COMPILER_OPTIONS: PluginOptions = {
     validateNoDerivedComputationsInEffects: true,
     // Temporarily enabled for internal testing
     enableUseKeyedState: true,
+    // Keep this explicit so eslint behavior does not depend on compiler defaults.
+    enableAllowSetStateFromRefsInEffects: true,
     enableVerboseNoSetStateInEffect: true,
     validateExhaustiveEffectDependencies: 'extra-only',
   },