prs/index.html at main · episphere/prs · GitHub

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<hr><h1>
PRS <sup style="font-size:medium">

    [<a href="https://github.com/episphere/prs" target="_blank">code</a>]
    [<a href="https://pubmed.ncbi.nlm.nih.gov/37868335" target="_blank">publication</a>]
    [<a href="https://observablehq.com/@lorenasandoval88/polygenic-risk-score-calc" target="_blank">notebook</a>]
    <!--[<a href="https://gitter.im/episphere/PRS">discussion</a>] -->
    [<img style = "vertical-align:bottom" src="youtube_img.png" class="Lgo" width="25" height="25" alt="playbutton">
    <a href="https://youtu.be/YXJjEZxHJhM" target="_blank">tutorial</a>]</sup>
<br><span style="font-size:medium;color:navy;font-weight:normal">Individual polygenic risk score calculation (<a href="https://www.nature.com/articles/nrg.2016.27" target="_blank">PRS</a>) for 23andme reports, using the <a href='https://www.pgscatalog.org' target="_blank">PGS Catalog</a>.</span>
<hr></hr>

<span style="font-size:small">Privacy notice:</span><span style="font-size:small;color:navy;font-weight:normal"> All data and calculations take place in the browser. No data or calculations circulate by a server. <b>This application is, foremost, an exercise in privacy-preserving biomedical informatics for consumer genomics data</b>.</span>
<br><span style="font-size:small;">Scope/Limitations:</span><span style="font-size:small;color:navy;font-weight:normal">This calculator was devised as an implementation proof of concept. It has a number of important limitations for epidemiology research and it does not meet criteria for clinical use. The current tool uses pre-imputation genotype data and thus results in a low number of SNP matches. Most important, only the relative risk model <a href='https://www.nature.com/articles/nrg.2016.27#Sec5' target="_blank">(Box 1, eq 2)</a> is calculated, with no effort to determine absolute risk of disease. Finally, the risk calculation will only be attempted for PGS catalog entries reporting effects as beta values under "effect_weight".</span>

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<head></head>

<!-- setting generic styling, borrowed from the parent page -->
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<link href="app.css" rel="stylesheet">

<script>
    (async ()=>{
        //pgs23 = await import('http://127.0.0.1:5501/export.js')
        //pgs23 = await import(location.href+'/export.js')
        pgs23 = await import('https://episphere.github.io/prs/export.js')
        pgs23.ui()
    })()
</script>


<script src="pgs.js"></script>

<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjs/3.3.0/math.min.js"></script>

</script>