Challenge 3 - Exploring genetic variation in motor neurone disease longevity to inform drug discovery
Recent genome-wide association study findings highlight the genetic component of motor neurone disease. Fifteen risk loci with distinct genetic architectures and neuron-specific biology provide vital clues to inform future drug discovery. This challenge will explore potential mechanisms and drug targets linked to these new findings.
The NGV hunters recognize the genetic complexity of Motor Neuron Disease and the multimodality of translating insight from motor neuron disease to effective drugs both for the (1) prevention of disease and for the (2) treatment of disease.
Docker images used
- VEP
- BCFtools
