-
Notifications
You must be signed in to change notification settings - Fork 4
Create a "Panel of Normals" #6
Copy link
Copy link
Open
Labels
>12 hoursThis task will probably take more than 12 hours to completeThis task will probably take more than 12 hours to completementally challengingif you don't have experience with genomics, this concept will challenge the way you see thingsif you don't have experience with genomics, this concept will challenge the way you see thingsquirks of the fieldYou will learn things that most people outside the field don't graspYou will learn things that most people outside the field don't grasp
Description
Metadata
Metadata
Assignees
Labels
>12 hoursThis task will probably take more than 12 hours to completeThis task will probably take more than 12 hours to completementally challengingif you don't have experience with genomics, this concept will challenge the way you see thingsif you don't have experience with genomics, this concept will challenge the way you see thingsquirks of the fieldYou will learn things that most people outside the field don't graspYou will learn things that most people outside the field don't grasp
Create a "Panel of Normals"
Aim
Read about what usually goes into a "panel of normals" (PON). Summarize what you find in a doc on the DCL overview wiki and present it to us at an SF Python Project Night.
Background
In my mind a PON is a consensus sequence. A consensus sequence is the mode (at each nucleotide) of a number of sequences. But what sequences do you use to make the consensus?
If we had non-tumor cells from the same patient we could use those to determine the 'normal' sequence. But many cancer samples don't have a matching non-tumor sample. For these cases what should we use?
Read more starting here: