diff --git a/requirements.txt b/requirements.txt
index 3001bb3e..f3d4ae9b 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,6 +1,6 @@
 mygene==3.1.0
 django_pandas==0.6.1
-Django==2.2.28
+Django==4.2.16
 networkx==2.4
 SQLAlchemy==1.3.16
 numpy==1.22.0