diff --git a/tests/podman/run-tests.sh b/tests/podman/run-tests.sh
index 8b108d4f5c..a98256ac2d 100755
--- a/tests/podman/run-tests.sh
+++ b/tests/podman/run-tests.sh
@@ -46,7 +46,10 @@ export TMPDIR=/var/tmp
 #
 # - Podman run with specified static IPv6 has correct IP
 #   Does not work inside test environment.
+#
+# - podman build and remove basic alpine with TMPDIR as relative
+#   Does not work inside container as upperdir is overlayfs (issue 1999).
 
-ginkgo --focus='.*' --skip='.*(selinux|notify_socket|systemd|podman run exit 12*|podman run exit code on failure to exec|failed to start|search|trust|inspect|logs|generate|import|mounted rw|inherit host devices|play kube|cgroups=disabled|privileged CapEff|device-cgroup-rule|capabilities|network|pull from docker|--add-host|removes a pod with a container|prune removes a pod with a stopped container|overlay volume flag|prune unused images|podman images filter|image list filter|create --pull|podman ps json format|using journald for container|image tree|--pull|shared layers|child images|cached images|flag with multiple mounts|overlay and used as workdir|image_copy_tmp_dir|Podman run with specified static IPv6 has correct IP|authenticated push|pod create --share-parent|podman kill paused container|login and logout|podman top on privileged container|local registry with authorization|podman update container all options v2|push test|podman pull and run on split imagestore|Podman kube play|uidmapping and gidmapping|push with --add-compression|enforces DiffID matching|push with authorization|artifact).*' \
+ginkgo --focus='.*' --skip='.*(selinux|notify_socket|systemd|podman run exit 12*|podman run exit code on failure to exec|failed to start|search|trust|inspect|logs|generate|import|mounted rw|inherit host devices|play kube|cgroups=disabled|privileged CapEff|device-cgroup-rule|capabilities|network|pull from docker|--add-host|removes a pod with a container|prune removes a pod with a stopped container|overlay volume flag|prune unused images|podman images filter|image list filter|create --pull|podman ps json format|using journald for container|image tree|--pull|shared layers|child images|cached images|flag with multiple mounts|overlay and used as workdir|image_copy_tmp_dir|Podman run with specified static IPv6 has correct IP|authenticated push|pod create --share-parent|podman kill paused container|login and logout|podman top on privileged container|local registry with authorization|podman update container all options v2|push test|podman pull and run on split imagestore|Podman kube play|uidmapping and gidmapping|push with --add-compression|enforces DiffID matching|push with authorization|artifact|podman build and remove basic alpine with TMPDIR as relative).*' \
 	 -vv -tags "seccomp ostree selinux exclude_graphdriver_devicemapper" \
 	 -timeout=50m -cover -flake-attempts 3 -progress -trace -no-color test/e2e/.