diff --git a/requirements.txt b/requirements.txt
index dfe100b..9cad308 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,5 +1,5 @@
-flask==3.1.1
-flask-cors==6.0.1
+fastapi==0.115.6
+uvicorn==0.30.6
 flexcache==0.3
 flexparser==0.3.1
 ipykernel==6.29.5
diff --git a/scripts/run_api.sh b/scripts/run_api.sh
new file mode 100755
index 0000000..109fec2
--- /dev/null
+++ b/scripts/run_api.sh
@@ -0,0 +1 @@
+uvicorn harmonization_framework.api.app:app --reload
diff --git a/scripts/run_flask.sh b/scripts/run_flask.sh
deleted file mode 100755
index f27e785..0000000
--- a/scripts/run_flask.sh
+++ /dev/null
@@ -1,4 +0,0 @@
-export FLASK_APP=src/harmonization_framework/api/app.py
-export FLASK_ENV=development
-
-flask run
diff --git a/src/harmonization_framework/api/app.py b/src/harmonization_framework/api/app.py
index 35ab300..d5548f4 100644
--- a/src/harmonization_framework/api/app.py
+++ b/src/harmonization_framework/api/app.py
@@ -1,11 +1,7 @@
-from flask import Flask
-from harmonization_framework.api.extensions import register_extensions
-from harmonization_framework.api.routes.health import health_blueprint
+from fastapi import FastAPI
 
-def create_app(config_name=None):
-    app = Flask(__name__, instance_relative_config=True)
-    
-    register_extensions(app)
+from harmonization_framework.api.routes.health import router as health_router
 
-    app.register_blueprint(health_blueprint, url_prefix="/health")
-    return app
+app = FastAPI(title="Harmonization Framework API")
+
+app.include_router(health_router, prefix="/health")
diff --git a/src/harmonization_framework/api/extensions.py b/src/harmonization_framework/api/extensions.py
deleted file mode 100644
index 6f65660..0000000
--- a/src/harmonization_framework/api/extensions.py
+++ /dev/null
@@ -1,4 +0,0 @@
-from flask_cors import CORS
-
-def register_extensions(app):
-    CORS(app)
diff --git a/src/harmonization_framework/api/harmonization_api_examples.md b/src/harmonization_framework/api/harmonization_api_examples.md
index 3a4851f..bc5de40 100644
--- a/src/harmonization_framework/api/harmonization_api_examples.md
+++ b/src/harmonization_framework/api/harmonization_api_examples.md
@@ -7,7 +7,7 @@ The following is a demo for using `curl` to interact with the Harmonization Fram
 ## Start API
 
 ```bash
-./scripts/run_flask.sh
+./scripts/run_api.sh
 ```
 
 ## Example Usage
diff --git a/src/harmonization_framework/api/routes/__init__.py b/src/harmonization_framework/api/routes/__init__.py
index 30b3e31..58055d8 100644
--- a/src/harmonization_framework/api/routes/__init__.py
+++ b/src/harmonization_framework/api/routes/__init__.py
@@ -1,7 +1,7 @@
 # src/api/routes/__init__.py
 
-from .health import health_blueprint
+from .health import router as health_router
 
 __all__ = [
-    "health_blueprint",
+    "health_router",
 ]
diff --git a/src/harmonization_framework/api/routes/health.py b/src/harmonization_framework/api/routes/health.py
index 16cfdbd..46e2245 100644
--- a/src/harmonization_framework/api/routes/health.py
+++ b/src/harmonization_framework/api/routes/health.py
@@ -1,7 +1,14 @@
-from flask import Blueprint, jsonify
+from fastapi import APIRouter
+from pydantic import BaseModel
 
-health_blueprint = Blueprint("health", __name__)
+router = APIRouter()
 
-@health_blueprint.route("/", methods=["GET"])
-def health_check():
-    return jsonify(status="ok", message="API is available"), 200
+
+class HealthResponse(BaseModel):
+    status: str
+    message: str
+
+
+@router.get("/")
+def health_check() -> HealthResponse:
+    return HealthResponse(status="ok", message="The harmonization API is available")