diff --git a/ci-targets.yaml b/ci-targets.yaml
index 1a8908c5..918dde6c 100644
--- a/ci-targets.yaml
+++ b/ci-targets.yaml
@@ -71,7 +71,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -92,7 +92,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -113,7 +113,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -134,7 +134,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -155,7 +155,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -262,12 +262,12 @@ linux:
       - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
           - freethreaded+noopt
-          - freethreaded+lto
+          - freethreaded+pgo+lto
         minimum-python-version: "3.13"
     run: true
 
@@ -288,12 +288,12 @@ linux:
       - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
           - freethreaded+noopt
-          - freethreaded+lto
+          - freethreaded+pgo+lto
         minimum-python-version: "3.13"
     run: true
 
@@ -314,12 +314,12 @@ linux:
       - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
           - freethreaded+noopt
-          - freethreaded+lto
+          - freethreaded+pgo+lto
         minimum-python-version: "3.13"
     run: true
 
@@ -340,12 +340,12 @@ linux:
       - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
           - freethreaded+noopt
-          - freethreaded+lto
+          - freethreaded+pgo+lto
         minimum-python-version: "3.13"
     run: true
 
@@ -366,12 +366,12 @@ linux:
       # - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
           - freethreaded+noopt
-          - freethreaded+lto
+          - freethreaded+pgo+lto
         minimum-python-version: "3.13"
     run: true
 
diff --git a/cpython-unix/build-cpython.sh b/cpython-unix/build-cpython.sh
index 8504fb8e..1c9c0540 100755
--- a/cpython-unix/build-cpython.sh
+++ b/cpython-unix/build-cpython.sh
@@ -466,8 +466,8 @@ if [ -n "${CPYTHON_OPTIMIZED}" ]; then
         CONFIGURE_FLAGS="${CONFIGURE_FLAGS} --enable-bolt"
     fi
 
-    # Allow users to enable the experimental JIT on 3.13+
-    if [[ -n "${PYTHON_MEETS_MINIMUM_VERSION_3_13}" ]]; then
+    # Allow users to enable the experimental JIT on 3.13+ (but not on musl)
+    if [[ -n "${PYTHON_MEETS_MINIMUM_VERSION_3_13}" && ! "${CC}" = "musl-clang" ]]; then
 
         # Do not enable on x86-64 macOS because the JIT requires macOS 11+ and we are currently
         # using 10.15 as a minimum version.