diff --git a/MODULE.bazel b/MODULE.bazel
index 1c7357715..3594fad8b 100644
--- a/MODULE.bazel
+++ b/MODULE.bazel
@@ -57,6 +57,9 @@ interpreters.configure(
         "20251031",
     ],
 )
+interpreters.toolchain(
+    python_version = "3.11",
+)
 interpreters.toolchain(
     python_version = "3.13",
 )
@@ -65,6 +68,14 @@ use_repo(
     "python_interpreters",
     # Individual platform repos — must be visible so the uv extension can
     # reference the host interpreter for sdist configure tooling.
+    "python_3_11_aarch64_apple_darwin",
+    "python_3_11_aarch64_unknown_linux_gnu",
+    "python_3_11_aarch64_unknown_linux_musl",
+    "python_3_11_i686_pc_windows_msvc",
+    "python_3_11_x86_64_apple_darwin",
+    "python_3_11_x86_64_pc_windows_msvc",
+    "python_3_11_x86_64_unknown_linux_gnu",
+    "python_3_11_x86_64_unknown_linux_musl",
     "python_3_13_aarch64_apple_darwin",
     "python_3_13_aarch64_unknown_linux_gnu",
     "python_3_13_aarch64_unknown_linux_musl",
diff --git a/py/private/py_pex_binary.bzl b/py/private/py_pex_binary.bzl
index c1a8579df..baf51a072 100644
--- a/py/private/py_pex_binary.bzl
+++ b/py/private/py_pex_binary.bzl
@@ -38,6 +38,9 @@ exclude_paths = [
     # these will match in bzlmod setup with --incompatible_use_plus_in_repo_names flag flipped.
     "rules_python++python+",
     "aspect_rules_py+/py/tools/",
+    # these will match the hermetic python interpreter from rules_py extension
+    "python_interpreters~",
+    "python_interpreters+",
 ]
 
 # determines if the given file is a `distinfo`, `dep` or a `source`
@@ -54,6 +57,11 @@ def _map_srcs(f, workspace):
         if dest_path.find(exclude) != -1:
             return []
 
+    if "_distutils_hack" in f.path:
+        return []
+    if "distutils-precedence.pth" in f.path:
+        return []
+
     site_packages_i = f.path.find("site-packages")
 
     # If the path contains 'site-packages', treat it as a third party dep
diff --git a/py/tests/py-pex-binary/BUILD.bazel b/py/tests/py-pex-binary/BUILD.bazel
index 98b65ae44..1e4292580 100644
--- a/py/tests/py-pex-binary/BUILD.bazel
+++ b/py/tests/py-pex-binary/BUILD.bazel
@@ -4,10 +4,12 @@ load("@bazel_skylib//rules:build_test.bzl", "build_test")
 load("//py:defs.bzl", "py_binary", "py_pex_binary")
 
 # Test that both single-file modules (six) and multi-file modules (cowsay) work with py_pex_binary.
+# Also tests that py_pex_binary works with hermetic Python toolchains (python_version = 3.11).
 py_binary(
     name = "print_modules_bin",
     srcs = ["print_modules.py"],
     data = ["data.txt"],
+    python_version = "3.11",
     deps = [
         "@pypi//cowsay",
         "@pypi//six",