diff --git a/packages/react-aria/src/selection/ListKeyboardDelegate.ts b/packages/react-aria/src/selection/ListKeyboardDelegate.ts
index 06e736447c6..8dab4534f9f 100644
--- a/packages/react-aria/src/selection/ListKeyboardDelegate.ts
+++ b/packages/react-aria/src/selection/ListKeyboardDelegate.ts
@@ -277,14 +277,14 @@ export class ListKeyboardDelegate<T> implements KeyboardDelegate {
     return null;
   }
 
-  getFirstKey(): Key | null {
-    let key = this.collection.getFirstKey();
-    return this.findNextNonDisabled(key, key => this.collection.getKeyAfter(key));
+  getFirstKey(key?: Key, includeDisabled?: boolean): Key | null {
+    let firstKey = this.collection.getFirstKey();
+    return this.findNextNonDisabled(firstKey, k => this.collection.getKeyAfter(k), includeDisabled);
   }
 
-  getLastKey(): Key | null {
-    let key = this.collection.getLastKey();
-    return this.findNextNonDisabled(key, key => this.collection.getKeyBefore(key));
+  getLastKey(key?: Key, includeDisabled?: boolean): Key | null {
+    let lastKey = this.collection.getLastKey();
+    return this.findNextNonDisabled(lastKey, k => this.collection.getKeyBefore(k), includeDisabled);
   }
 
   getKeyPageAbove(key: Key): Key | null {
diff --git a/packages/react-aria/src/selection/useSelectableCollection.ts b/packages/react-aria/src/selection/useSelectableCollection.ts
index a8599907985..56700c37f91 100644
--- a/packages/react-aria/src/selection/useSelectableCollection.ts
+++ b/packages/react-aria/src/selection/useSelectableCollection.ts
@@ -450,7 +450,11 @@ export function useSelectableCollection(
       ) {
         navigateToKey(manager.lastSelectedKey ?? delegate.getLastKey?.());
       } else {
-        navigateToKey(manager.firstSelectedKey ?? delegate.getFirstKey?.());
+        let firstKey = manager.firstSelectedKey ?? delegate.getFirstKey?.();
+        if (firstKey && manager.disabledKeys.has(firstKey)) {
+          firstKey = delegate.getFirstKey?.();
+        }
+        navigateToKey(firstKey);
       }
     } else if (scrollRef.current) {
       // Restore the scroll position to what it was before.
@@ -572,17 +576,27 @@ export function useSelectableCollection(
       let selectedKeys = manager.selectedKeys;
       if (selectedKeys.size) {
         for (let key of selectedKeys) {
-          if (manager.canSelectItem(key)) {
+          if (manager.canSelectItem(key) && !manager.disabledKeys.has(key)) {
             focusedKey = key;
             break;
           }
         }
       }
 
+      if (focusedKey == null || manager.disabledKeys.has(focusedKey)) {
+        let firstEnabledKey = delegate.getFirstKey?.() ?? null;
+
+        if (firstEnabledKey != null) {
+          focusedKey = firstEnabledKey;
+        }
+      }
+
       manager.setFocused(true);
-      manager.setFocusedKey(focusedKey);
 
-      // If no default focus key is selected, focus the collection itself.
+      if (focusedKey != null) {
+        manager.setFocusedKey(focusedKey);
+      }
+
       if (focusedKey == null && !shouldUseVirtualFocus && ref.current) {
         focusSafely(ref.current);
       }
diff --git a/packages/react-aria/test/selection/useSelectableCollection.test.js b/packages/react-aria/test/selection/useSelectableCollection.test.js
index 294743740b3..fc99ad9e35b 100644
--- a/packages/react-aria/test/selection/useSelectableCollection.test.js
+++ b/packages/react-aria/test/selection/useSelectableCollection.test.js
@@ -157,4 +157,47 @@ describe('useSelectableCollection', () => {
       expect(onSelectionChange2).not.toHaveBeenCalled();
     });
   });
+  // =========================================================================
+  // ADDED: Tests for skipping disabled items automatically on mount/focus
+  // =========================================================================
+  describe('with disabled items boundary keys', () => {
+    it('should automatically focus the first available option when the first 2 options are disabled on autoFocus', async () => {
+      let {getAllByRole} = render(
+        <List selectionMode="single" autoFocus="first" disabledKeys={['i1', 'i2']}>
+          <Item key="i1">Disabled Item 1</Item>
+          <Item key="i2">Disabled Item 2</Item>
+          <Item key="i3">First Enabled Item</Item>
+          <Item key="i4">Second Enabled Item</Item>
+        </List>
+      );
+
+      let options = getAllByRole('option');
+
+      // Let any asynchronous layout microtasks complete smoothly
+      await new Promise(resolve => setTimeout(resolve, 0));
+
+      expect(document.activeElement).toBe(options[2]);
+      expect(options[2].textContent).toBe('First Enabled Item');
+    });
+
+    it('should automatically focus the first available option when tabbing into the collection with leading disabled keys', async () => {
+      let {getAllByRole} = render(
+        <List selectionMode="single" disabledKeys={['i1', 'i2']}>
+          <Item key="i1">Disabled Item 1</Item>
+          <Item key="i2">Disabled Item 2</Item>
+          <Item key="i3">First Enabled Item</Item>
+          <Item key="i4">Second Enabled Item</Item>
+        </List>
+      );
+
+      let options = getAllByRole('option');
+
+      // Wrap the simulated user tabbing action cleanly in an async act block
+      // to handle the synchronous JSDOM focus state mutation
+      await user.tab();
+
+      expect(document.activeElement).toBe(options[2]);
+      expect(options[2].textContent).toBe('First Enabled Item');
+    });
+  });
 });