Vectorworks 2015 is a 64-bit application. This does not affect VectorScript in any way as it does not support any of the extended types. Python Scripting is affected only by the fact that now Vectorworks uses the 64-bit Python engine.
In addition, the deprecated layout manager functions in Vectorworks 2010 have been removed. Consult here Vectorworks 2010 for a table of substitutes.
VS:Vectorworks 2015 New Functions