Code accompanying Robinson, Coorens, Palles et al (2021) Increased somatic mutation burdens in normal human cells due to defective DNA polymerases. Nature Genetics 53: 1434-1442.
The file 'DNAPolymerase_NG_somatic_SBS_ID_combined.txt.zip' contains all the somatic single-base substitution and indel calls.
This folder contains all the scripts and input materials to follow the mutational signature extraction, signature decomposition, and refitting of those signatures to the observed mutational counts.
This folder contains the code and input material necessary to recreate the four main figures of the paper.