add paper

Author: Josh Zhang

_bibliography/papers.bib

@@ -16,4 +16,19 @@ @article{Ooi2025
   altmetric={true},
   dimensions={pub.1190840505},
   selected={true},
+}
+
+@article{Zhang2024,
+  abbr={PNAS},
+  title={In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth},
+  author={Zhang*, S. and Larsen*, B. and Sydnor*, V. and others},
+  abstract={A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I ratio remains unknown. Here, we noninvasively estimate a putative marker of whole-cortex E/I ratio by fitting a large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our model generates realistic brain dynamics in the Human Connectome Project. Next, we show that the estimated E/I ratio marker is sensitive to the gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced E/I changes are spatially consistent with positron emission tomography measurement of benzodiazepine receptor density. We then investigate the relationship between the E/I ratio marker and neurodevelopment. We find that the E/I ratio marker declines heterogeneously across the cerebral cortex during youth, with the greatest reduction occurring in sensorimotor systems relative to association systems. Importantly, among children with the same chronological age, a lower E/I ratio marker (especially in the association cortex) is linked to better cognitive performance. This result is replicated across North American (8.2 to 23.0 y old) and Asian (7.2 to 7.9 y old) cohorts, suggesting that a more mature E/I ratio indexes improved cognition during normative development. Overall, our findings open the door to studying how disrupted E/I trajectories may lead to cognitive dysfunction in psychopathology that emerges during youth.},
+  journal={PNAS},
+  year={2024},
+  month={April},
+  doi={https://doi.org/10.1073/pnas.2318641121},
+  pdf={2024_Zhang_in-vivo-whole-cortex-marker-of-excitation-inhibition-ratio-indexes-cortical-maturation-and-cognitive.pdf},
+  altmetric={true},
+  dimensions={pub.1172270883},
+  selected={true},
 }

_data/coauthors.yml

@@ -5,3 +5,12 @@
 "orban":
   - firstname: ["Csaba", "C."]
     url: https://scholar.google.com/citations?user=ZyiA3lAAAAAJ&hl=en
+
+"larsen":
+  - firstname: ["Bart", "B."]
+    url: https://scholar.google.com/citations?user=GEPAHz4AAAAJ&hl=en
+
+"Sydnor":
+  - firstname: ["Valerie", "V."]
+    url: https://scholar.google.com/citations?user=_bvWdrgAAAAJ&hl=en
+   

_news/news_250716.md

@@ -5,4 +5,4 @@ inline: true
 related_posts: false
 ---
 
-Our latest work looking into the optimal fMRI scan time for brain-wide association studies is now out at <a href='https://www.nature.com/articles/s41586-025-09250-1'>Nature</a>.
+Our work looking into the optimal fMRI scan time for brain-wide association studies is now out at <a href='https://www.nature.com/articles/s41586-025-09250-1'>Nature</a>.