diff --git a/monai/auto3dseg/analyzer.py b/monai/auto3dseg/analyzer.py
index d48d5fc878..a731546a9e 100644
--- a/monai/auto3dseg/analyzer.py
+++ b/monai/auto3dseg/analyzer.py
@@ -15,7 +15,7 @@
 from abc import ABC, abstractmethod
 from collections.abc import Hashable, Mapping
 from copy import deepcopy
-from typing import Any
+from typing import Any, cast
 
 import numpy as np
 import torch
@@ -470,6 +470,7 @@ def __call__(self, data: Mapping[Hashable, MetaTensor]) -> dict[Hashable, MetaTe
         start = time.time()
         image_tensor = d[self.image_key]
         label_tensor = d[self.label_key]
+        # Check if either tensor is on CUDA to determine if we should move both to CUDA for processing
         using_cuda = any(
             isinstance(t, (torch.Tensor, MetaTensor)) and t.device.type == "cuda" for t in (image_tensor, label_tensor)
         )
@@ -480,7 +481,13 @@ def __call__(self, data: Mapping[Hashable, MetaTensor]) -> dict[Hashable, MetaTe
             label_tensor, (MetaTensor, torch.Tensor)
         ):
             if label_tensor.device != image_tensor.device:
-                label_tensor = label_tensor.to(image_tensor.device)  # type: ignore
+                if using_cuda:
+                    # Move both tensors to CUDA when mixing devices
+                    cuda_device = image_tensor.device if image_tensor.device.type == "cuda" else label_tensor.device
+                    image_tensor = cast(MetaTensor, image_tensor.to(cuda_device))
+                    label_tensor = cast(MetaTensor, label_tensor.to(cuda_device))
+                else:
+                    label_tensor = cast(MetaTensor, label_tensor.to(image_tensor.device))
 
         ndas: list[MetaTensor] = [image_tensor[i] for i in range(image_tensor.shape[0])]  # type: ignore
         ndas_label: MetaTensor = label_tensor.astype(torch.int16)  # (H,W,D)
diff --git a/tests/apps/test_auto3dseg.py b/tests/apps/test_auto3dseg.py
index 2159265873..6c840e944d 100644
--- a/tests/apps/test_auto3dseg.py
+++ b/tests/apps/test_auto3dseg.py
@@ -393,6 +393,7 @@ def test_label_stats_mixed_device_analyzer(self, input_params):
         result = analyzer({"image": image_tensor, "label": label_tensor})
         report = result["label_stats"]
 
+        # Verify report format and computation succeeded despite mixed/unified devices
         assert verify_report_format(report, analyzer.get_report_format())
         assert report[LabelStatsKeys.LABEL_UID] == [0, 1]