From d1970baa646e740f76a7c6718856c5be37f946a7 Mon Sep 17 00:00:00 2001 From: EnfxcFCb6 Date: Mon, 2 Jun 2025 12:41:08 -0400 Subject: [PATCH 1/2] Standardized README to Markdown format --- readme.html => README.md | 42 ++++++++++++++++++++-------------------- 1 file changed, 21 insertions(+), 21 deletions(-) rename readme.html => README.md (59%) diff --git a/readme.html b/README.md similarity index 59% rename from readme.html rename to README.md index d5a0343..b11f053 100644 --- a/readme.html +++ b/README.md @@ -1,12 +1,10 @@ -
-This is the readme for th model associated with the papers:
+This is the readme for the model associated with the papers:
 
-1. Huang et al., The synergistic inhibitory actions of oxcarbazepine
-   on voltage- gated sodium and potassium currents in differentiated
-   NG108-15 neuronal cells and model neurons. Int J
-   Neuropsychopharmacol 2008;11:597-610.
+# 1. Huang et al., The synergistic inhibitory actions of oxcarbazepine
+on voltage-gated sodium and potassium currents in differentiated
+NG108-15 neuronal cells and model neurons. *Int J Neuropsychopharmacol* 2008;11:597-610.
 
-Abstract:
+## Abstract:
 
 Oxcarbazepine (OXC), one of the newer anti-epileptic drugs, has been
 demonstrating its efficacy on wide-spectrum neuropsychiatric
@@ -14,13 +12,13 @@
 remains incompletely understood. With the aid of patch-clamp
 technology, we first investigated the effects of OXC on ion currents
 in NG108-15 neuronal cells differentiated with cyclic AMP. We found
-OXC (0.3-30 mum) caused a reversible reduction in the amplitude of
-voltage-gated Na+ current (INa).  The IC50 value required for the
-inhibition of INa by OXC was 3.1 mum. OXC (3 mum) could shift the
+OXC (0.3-30 μM) caused a reversible reduction in the amplitude of
+voltage-gated Na+ current (INa). The IC50 value required for the
+inhibition of INa by OXC was 3.1 μM. OXC (3 μM) could shift the
 steady-state inactivation of INa to a more negative membrane potential
-by approximately -9 mV with no effect on the slope of the inactivation
+by approximately −9 mV with no effect on the slope of the inactivation
 curve, and produce a significant prolongation in the recovery of INa
-inactivation.  Additionally, OXC was effective in suppressing
+inactivation. Additionally, OXC was effective in suppressing
 persistent INa (INa(P)) elicited by long ramp pulses. The blockade of
 INa by OXC does not simply reduce current magnitude, but alters
 current kinetics. Moreover, OXC could suppress the amplitude of
@@ -34,20 +32,22 @@
 blocking effects on INa and IK(DR) may contribute to the underlying
 mechanisms through which OXC affects neuronal function in vivo.
 
+## To run the model:
 
-To run the model:
-Expand the archive and cd into the newly created directory and run:
-xppaut neuron_oxc.ode
-then click on Initialcond -> Go
-The potential trace is shown in the lower part of Figure 9b in the paper of 
-Huang et al (2008):
+- Expand the archive and cd into the newly created directory and run:
+  `xppaut neuron_oxc.ode`
+- Then click on Initialcond -> Go
+- The potential trace is shown in the lower part of Figure 9b in the paper of Huang et al (2008):
 
-screenshot
+![screenshot](./Neuron_OXC.JPG)
 
-The model file was supplied by:
+## The model file was supplied by:
 
 Dr. Sheng-Nan Wu
 National Cheng Kung University Medical College
 Tainan 70101, Taiwan
 snwu@mail.ncku.edu.tw
-
+ +--- + +2025-06-02: Standardized to Markdown. \ No newline at end of file From 582832e403770e2d0a1f7229e8ce9baec342d411 Mon Sep 17 00:00:00 2001 From: rsakai Date: Mon, 2 Jun 2025 13:33:10 -0400 Subject: [PATCH 2/2] Update README.md --- README.md | 10 +++++----- 1 file changed, 5 insertions(+), 5 deletions(-) diff --git a/README.md b/README.md index b11f053..0286a56 100644 --- a/README.md +++ b/README.md @@ -39,15 +39,15 @@ mechanisms through which OXC affects neuronal function in vivo. - Then click on Initialcond -> Go - The potential trace is shown in the lower part of Figure 9b in the paper of Huang et al (2008): -![screenshot](./Neuron_OXC.JPG) +![screenshot](./neuron_OXC.JPG) ## The model file was supplied by: -Dr. Sheng-Nan Wu -National Cheng Kung University Medical College -Tainan 70101, Taiwan +Dr. Sheng-Nan Wu +National Cheng Kung University Medical College +Tainan 70101, Taiwan snwu@mail.ncku.edu.tw --- -2025-06-02: Standardized to Markdown. \ No newline at end of file +2025-06-02: Standardized to Markdown.