diff --git a/readme.html b/README.md
similarity index 55%
rename from readme.html
rename to README.md
index d5a0343..0286a56 100644
--- a/readme.html
+++ b/README.md
@@ -1,12 +1,10 @@
-
-This is the readme for th model associated with the papers:
+This is the readme for the model associated with the papers:
-1. Huang et al., The synergistic inhibitory actions of oxcarbazepine
- on voltage- gated sodium and potassium currents in differentiated
- NG108-15 neuronal cells and model neurons. Int J
- Neuropsychopharmacol 2008;11:597-610.
+# 1. Huang et al., The synergistic inhibitory actions of oxcarbazepine
+on voltage-gated sodium and potassium currents in differentiated
+NG108-15 neuronal cells and model neurons. *Int J Neuropsychopharmacol* 2008;11:597-610.
-Abstract:
+## Abstract:
Oxcarbazepine (OXC), one of the newer anti-epileptic drugs, has been
demonstrating its efficacy on wide-spectrum neuropsychiatric
@@ -14,13 +12,13 @@
remains incompletely understood. With the aid of patch-clamp
technology, we first investigated the effects of OXC on ion currents
in NG108-15 neuronal cells differentiated with cyclic AMP. We found
-OXC (0.3-30 mum) caused a reversible reduction in the amplitude of
-voltage-gated Na+ current (INa). The IC50 value required for the
-inhibition of INa by OXC was 3.1 mum. OXC (3 mum) could shift the
+OXC (0.3-30 μM) caused a reversible reduction in the amplitude of
+voltage-gated Na+ current (INa). The IC50 value required for the
+inhibition of INa by OXC was 3.1 μM. OXC (3 μM) could shift the
steady-state inactivation of INa to a more negative membrane potential
-by approximately -9 mV with no effect on the slope of the inactivation
+by approximately −9 mV with no effect on the slope of the inactivation
curve, and produce a significant prolongation in the recovery of INa
-inactivation. Additionally, OXC was effective in suppressing
+inactivation. Additionally, OXC was effective in suppressing
persistent INa (INa(P)) elicited by long ramp pulses. The blockade of
INa by OXC does not simply reduce current magnitude, but alters
current kinetics. Moreover, OXC could suppress the amplitude of
@@ -34,20 +32,22 @@
blocking effects on INa and IK(DR) may contribute to the underlying
mechanisms through which OXC affects neuronal function in vivo.
+## To run the model:
-To run the model:
-Expand the archive and cd into the newly created directory and run:
-xppaut neuron_oxc.ode
-then click on Initialcond -> Go
-The potential trace is shown in the lower part of Figure 9b in the paper of
-Huang et al (2008):
+- Expand the archive and cd into the newly created directory and run:
+ `xppaut neuron_oxc.ode`
+- Then click on Initialcond -> Go
+- The potential trace is shown in the lower part of Figure 9b in the paper of Huang et al (2008):
-
+
-The model file was supplied by:
+## The model file was supplied by:
-Dr. Sheng-Nan Wu
-National Cheng Kung University Medical College
-Tainan 70101, Taiwan
+Dr. Sheng-Nan Wu
+National Cheng Kung University Medical College
+Tainan 70101, Taiwan
snwu@mail.ncku.edu.tw
-
+
+---
+
+2025-06-02: Standardized to Markdown.