diff --git a/CMake/ITKModuleExternal.cmake b/CMake/ITKModuleExternal.cmake
index 0aa1b236f31..c750c7d65c0 100644
--- a/CMake/ITKModuleExternal.cmake
+++ b/CMake/ITKModuleExternal.cmake
@@ -75,55 +75,18 @@ if(NOT DEFINED CMAKE_INSTALL_LIBDIR)
   set(CMAKE_INSTALL_LIBDIR "lib")
 endif()
 
-# The default path when not wrapping.  Restore standard build location
-# if python wrapping is turned on, and then turned off.
+# When Wrapping is enabled the CMAKE_*_OUTPUT_DIRECTORY(s) will be explicitly set
+include(WrappingConfigCommon)
+
+# Only set default if not prior configured by wrapping or the user
 if(NOT CMAKE_LIBRARY_OUTPUT_DIRECTORY)
-  set(
-    NO_WRAP_CMAKE_LIBRARY_OUTPUT_DIRECTORY
-    ${ITK_BINARY_DIR}/${CMAKE_INSTALL_LIBDIR}
-    CACHE PATH
-    "Shared library directory"
-  )
-else()
-  set(
-    NO_WRAP_CMAKE_LIBRARY_OUTPUT_DIRECTORY
-    ${CMAKE_LIBRARY_OUTPUT_DIRECTORY}
-    CACHE PATH
-    "Shared library directory"
-  )
+  set(CMAKE_LIBRARY_OUTPUT_DIRECTORY ${ITK_BINARY_DIR}/${CMAKE_INSTALL_LIBDIR})
 endif()
 if(NOT CMAKE_RUNTIME_OUTPUT_DIRECTORY)
-  set(
-    NO_WRAP_CMAKE_RUNTIME_OUTPUT_DIRECTORY
-    ${ITK_BINARY_DIR}/bin
-    CACHE PATH
-    "Shared library directory"
-  )
-else()
-  set(
-    NO_WRAP_CMAKE_RUNTIME_OUTPUT_DIRECTORY
-    ${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
-    CACHE PATH
-    "Shared library directory"
-  )
+  set(CMAKE_RUNTIME_OUTPUT_DIRECTORY ${ITK_BINARY_DIR}/bin)
 endif()
-
-include(WrappingConfigCommon)
-# Setup build locations for shared libraries ----STOP
-
 if(NOT CMAKE_ARCHIVE_OUTPUT_DIRECTORY)
-  set(
-    CMAKE_ARCHIVE_OUTPUT_DIRECTORY
-    ${ITK_DIR}/${CMAKE_INSTALL_LIBDIR}
-    CACHE PATH
-    "Static library install directory"
-  )
-  set(
-    CMAKE_RUNTIME_OUTPUT_DIRECTORY
-    ${NO_WRAP_CMAKE_RUNTIME_OUTPUT_DIRECTORY}
-    CACHE PATH
-    "Runtime library directory"
-  )
+  set(CMAKE_ARCHIVE_OUTPUT_DIRECTORY ${ITK_BINARY_DIR}/${CMAKE_INSTALL_LIBDIR})
 endif()
 
 # ITK installation structure
diff --git a/CMake/WrappingConfigCommon.cmake b/CMake/WrappingConfigCommon.cmake
index 84d1e576dae..3ab2272840e 100644
--- a/CMake/WrappingConfigCommon.cmake
+++ b/CMake/WrappingConfigCommon.cmake
@@ -41,40 +41,8 @@ if(ITK_WRAPPING)
     # When wrapping, the multi-config generators can only be used in degraded state
     # of allowing only a single element int the CMAKE_CONFIGURATION_TYPES and enforcing
     # that CMAKE_BUILD_TYPE match that type (see Wrapping/CMakeLists.txt enforcement)
-    set(
-      CMAKE_LIBRARY_OUTPUT_DIRECTORY
-      "$<1:${ITK_PYTHON_PACKAGE_DIR}>"
-      CACHE PATH
-      "Shared library directory with generator override"
-      FORCE
-    )
-    set(
-      CMAKE_RUNTIME_OUTPUT_DIRECTORY
-      "$<1:${ITK_PYTHON_PACKAGE_DIR}>"
-      CACHE PATH
-      "Shared library directory with generator override"
-      FORCE
-    )
+    set(CMAKE_LIBRARY_OUTPUT_DIRECTORY "$<1:${ITK_PYTHON_PACKAGE_DIR}>")
+    set(CMAKE_RUNTIME_OUTPUT_DIRECTORY "$<1:${ITK_PYTHON_PACKAGE_DIR}>")
   endif()
-else()
-  set(
-    CMAKE_LIBRARY_OUTPUT_DIRECTORY
-    ${NO_WRAP_CMAKE_LIBRARY_OUTPUT_DIRECTORY}
-    CACHE PATH
-    "Shared library directory"
-  )
-  set(
-    CMAKE_RUNTIME_OUTPUT_DIRECTORY
-    ${NO_WRAP_CMAKE_RUNTIME_OUTPUT_DIRECTORY}
-    CACHE PATH
-    "Runtime library directory"
-  )
 endif()
-mark_as_advanced(
-  FORCE
-  CMAKE_RUNTIME_OUTPUT_DIRECTORY
-  CMAKE_LIBRARY_OUTPUT_DIRECTORY
-  NO_WRAP_CMAKE_LIBRARY_OUTPUT_DIRECTORY
-  NO_WRAP_CMAKE_RUNTIME_OUTPUT_DIRECTORY
-  Python3_ROOT_DIR
-)
+mark_as_advanced(FORCE Python3_ROOT_DIR)
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 8050af1e14a..988ea72ad77 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -345,44 +345,22 @@ if(NOT DEFINED CMAKE_FIND_USE_PACKAGE_REGISTRY)
   set(CMAKE_FIND_USE_PACKAGE_REGISTRY 0)
 endif()
 
-# Setup build locations for shared libraries ----START
-#     ITK/CMakeLists.txt -- use ITK_BINARY_DIR as root
-#     ITK/CMake/ITKModuleExternal.cmake -- use ITK_DIR as root
+# Setup build locations for libraries ----START
 #
-# The default path when not wrapping.  Restore standard build location
-# if python wrapping is turned on, and then turned off.
+# When Wrapping is enabled the CMAKE_*_OUTPUT_DIRECTORY(s) will be explicitly set
+include(WrappingConfigCommon)
+
+# Only set default is not prior configured by wrapping or the user
 if(NOT CMAKE_LIBRARY_OUTPUT_DIRECTORY)
-  set(
-    NO_WRAP_CMAKE_LIBRARY_OUTPUT_DIRECTORY
-    ${ITK_BINARY_DIR}/${CMAKE_INSTALL_LIBDIR}
-    CACHE PATH
-    "Shared library directory"
-  )
-else()
-  set(
-    NO_WRAP_CMAKE_LIBRARY_OUTPUT_DIRECTORY
-    ${CMAKE_LIBRARY_OUTPUT_DIRECTORY}
-    CACHE PATH
-    "Shared library directory"
-  )
+  set(CMAKE_LIBRARY_OUTPUT_DIRECTORY ${ITK_BINARY_DIR}/${CMAKE_INSTALL_LIBDIR})
 endif()
 if(NOT CMAKE_RUNTIME_OUTPUT_DIRECTORY)
-  set(
-    NO_WRAP_CMAKE_RUNTIME_OUTPUT_DIRECTORY
-    ${ITK_BINARY_DIR}/bin
-    CACHE PATH
-    "Shared library directory"
-  )
-else()
-  set(
-    NO_WRAP_CMAKE_RUNTIME_OUTPUT_DIRECTORY
-    ${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
-    CACHE PATH
-    "Shared library directory"
-  )
+  set(CMAKE_RUNTIME_OUTPUT_DIRECTORY ${ITK_BINARY_DIR}/bin)
+endif()
+if(NOT CMAKE_ARCHIVE_OUTPUT_DIRECTORY)
+  set(CMAKE_ARCHIVE_OUTPUT_DIRECTORY ${ITK_BINARY_DIR}/${CMAKE_INSTALL_LIBDIR})
 endif()
 
-include(WrappingConfigCommon)
 # Setup build locations for shared libraries ----STOP
 
 if(CMAKE_CONFIGURATION_TYPES AND ITK_WRAPPING)
@@ -399,9 +377,6 @@ if(CMAKE_CONFIGURATION_TYPES AND ITK_WRAPPING)
   )
 endif()
 
-if(NOT CMAKE_ARCHIVE_OUTPUT_DIRECTORY)
-  set(CMAKE_ARCHIVE_OUTPUT_DIRECTORY ${ITK_BINARY_DIR}/${CMAKE_INSTALL_LIBDIR})
-endif()
 set(ITK_MODULES_DIR "${ITK_BINARY_DIR}/${ITK_INSTALL_PACKAGE_DIR}/Modules")
 
 #-----------------------------------------------------------------------------
diff --git a/Wrapping/CMakeLists.txt b/Wrapping/CMakeLists.txt
index 2e4f2b59020..1f4d8c95cd3 100644
--- a/Wrapping/CMakeLists.txt
+++ b/Wrapping/CMakeLists.txt
@@ -60,22 +60,8 @@ set(
 )
 
 if(NOT CMAKE_LIBRARY_OUTPUT_DIRECTORY)
-  # See ITK/CMakeLists.txt for rational for overwriting multi-config default behavior of appending $<CONFIG>
-  set(
-    CMAKE_LIBRARY_OUTPUT_DIRECTORY
-    "$<1:${WrapITK_BINARY_DIR}/lib>"
-    CACHE INTERNAL
-    "Single output directory for building all libraries."
-  )
-endif()
-
-if(NOT EXECUTABLE_OUTPUT_PATH)
-  set(
-    EXECUTABLE_OUTPUT_PATH
-    ${WrapITK_BINARY_DIR}/bin
-    CACHE INTERNAL
-    "Single output directory for building all executables."
-  )
+  # See ITK/WrappingConfigCommon.cmake for rational for overwriting multi-config default behavior of appending $<CONFIG>
+  set(CMAKE_LIBRARY_OUTPUT_DIRECTORY "$<1:${WrapITK_BINARY_DIR}/lib>")
 endif()
 
 # Set WRAP_ITK_INSTALL_COMPONENT_IDENTIFIER to a non-null value, like
@@ -97,12 +83,9 @@ endif()
 
 mark_as_advanced(
   CMAKE_LIBRARY_OUTPUT_DIRECTORY
-  EXECUTABLE_OUTPUT_PATH
   WRAP_ITK_INSTALL_PREFIX
 )
 
-set(CXX_TEST_PATH ${EXECUTABLE_OUTPUT_PATH})
-
 ###############################################################################
 # Additional files for installation
 ###############################################################################