diff --git a/requirements.txt b/requirements.txt
index 499fc1c..7293b75 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -9,7 +9,7 @@ flake8==3.7.7
 gffutils==0.9
 numpy==1.19.1
 requests==2.20.0
-setuptools==40.4.3
+setuptools==65.5.1
 setuptools_scm==3.1.0
 h5py==2.10.0
 tables==3.4.4
\ No newline at end of file