Thanks for developing REDItools2. It’s a nice tool to use. I’ve got some questions about using the tool.
I have 2 groups with 3 replicates in each group. I identified RNA editing events in each sample (replicate) using REDItools2. REDItools2 identified ~300,000 AG editing events in each sample.
Now I want to do differential RNA editing analysis between the 2 groups. I noticed REDItools2 doesn’t provide differential RNA editing analysis. I tried to use the same method for DE analysis (gene) but found there is little overlap of editing events identified among samples. Among ~300,000 AG editing events, there are only ~8000 common editing events among the 6 samples across the 2 groups.
Could you please advise me on how to do differential analysis with the REDItools2 results? Thank you so much.
Thanks for developing REDItools2. It’s a nice tool to use. I’ve got some questions about using the tool.
I have 2 groups with 3 replicates in each group. I identified RNA editing events in each sample (replicate) using REDItools2. REDItools2 identified ~300,000 AG editing events in each sample.
Now I want to do differential RNA editing analysis between the 2 groups. I noticed REDItools2 doesn’t provide differential RNA editing analysis. I tried to use the same method for DE analysis (gene) but found there is little overlap of editing events identified among samples. Among ~300,000 AG editing events, there are only ~8000 common editing events among the 6 samples across the 2 groups.
Could you please advise me on how to do differential analysis with the REDItools2 results? Thank you so much.