fix/substanceState: Valid PD def for epinephrine and chloride ratio

Author: mcmcdaniel

share/data/BioGears.xlsx

@@ -28,7 +28,7 @@ Renal Dynamics Choices,,,,,,,,,,,,,,,,  ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
 or all below,,,,,,,,,,,,,,,,  ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
      ChargeInBlood,,,,,Negative,Positive,Negative,Positive,Positive,,,,Positive,Positive,Neutral,Neutral,Negative,,Neutral,,,,,,,,,,Neutral,,,,,,,,,,,,,Negative,,,,,,,,,,,,
      FractionUnboundInPlasma,,,,,1,1,1,1,1,,,,1,1,1,1,1,,1,,,,,,,,,,0.55,,,,,,,,,,,,,1,,,,,,,,,,,,
-     ReabsorptionRatio,,,,,12.5,0.8,1.4,3,1.8,,,,INF,0,INF,INF,0.114,,0.001,,,,,,,,,,1,,,,,,,,,,,,,INF,,,,,,,,,,,,
+     ReabsorptionRatio,,,,,12.5,0.8,0.9,3,1.8,,,,INF,0,INF,INF,0.114,,0.001,,,,,,,,,,1,,,,,,,,,,,,,INF,,,,,,,,,,,,
      TransportMaximum,,,,,INF mg/min,INF mg/min,INF mg/min,INF mg/min,INF mg/min,,,,INF mg/min,0.0 g/min,0.375 g/min,INF mg/min,0.075 g/min,,INF mg/min,,,,,,,,,,INF mg/min,,,,,,,,,,,,,30 mg/min,,,,,,,,,,,,
 Cell Regulation,,,,,,,,,,,,,,,,  ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
 CellDeathRate,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,2.0E6 1/s,2.0E6 1/s,4.63E6 1/s,2.0E6 1/s,1.16E5 1/s
@@ -47,7 +47,7 @@ Bronchodilation,,,,,,,,,,0.3,,,,,,,,,,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,-0.8,0,,
 DiastolicPressureModifier,,,,,,,,,,-0.25,,,,,,,,,,0,0,-0.45,0,-0.05,0,0,-0.25,-0.15,0,0,0.45,0,0,0,-0.25,-0.2,-0.1,-0.15,,0,1,,,,,,,,,,,,,
 EC50,,,,,,,,,,0.0009 ug/mL,,,,,,,,,,5.17 ug/mL,0.000031 ug/mL,100 ug/mL,0.029 mg/L,0.004 ug/mL,0.4462 ug/mL,0.4319 ug/mL,0.0558 ug/mL,0.075 ug/mL,0.1 mg/L,0.0015 ug/mL,0.008 ug/mL,2.0 ug/mL,0.2855 ug/mL,0.2232 ug/mL,0.7649 ug/mL,0.5549 ug/mL,0.5 ug/mL,0.5811 ug/mL,,60.0 ug/mL,0.0003 ug/mL,,,,,,,,,,,,,
 EMaxShapeParameter,,,,,,,,,,10,,,,,,,,,,9.98,1,10,1,3,1,1,1,1,1,1,1.8,2,1,1,1,1,1,1,,5.5,1,,,,,,,,,,,,,
-FeverModifier,,,,,,,,,,,,,,,,,,,,0.1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,,0,0,,,,,,,,,,,,,
+FeverModifier,,,,,,,,,,0,,,,,,,,,,0.1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,,0,0,,,,,,,,,,,,,
 HeartRateModifier,,,,,,,,,,0.45,,,,,,,,,,0,0.3,0.4,0,-0.01,0,0.2,0.3,-0.06,0,0,0,0,0,0,0.15,0.2,-0.1,0.05,,0,0,,,,,,,,,,,,,
 HemorrhageModifier,,,,,,,,,,0,,,,,,,,,,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,,-0.597,0,,,,,,,,,,,,,
 NeuromuscularBlock,,,,,,,,,,0,,,,,,,,,,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,,0,0,,,,,,,,,,,,,

share/data/Substances.csv

@@ -10,7 +10,7 @@
       <Regulation>
         <ChargeInBlood>Negative</ChargeInBlood>
         <FractionUnboundInPlasma readOnly="false" value="1"/>
-        <ReabsorptionRatio readOnly="false" value="1.4"/>
+        <ReabsorptionRatio readOnly="false" value="0.9"/>
         <TransportMaximum readOnly="false" unit="mg/min" value="INF"/>
       </Regulation>
     </RenalDynamics>

share/data/substances/Chloride.xml

@@ -27,4 +27,27 @@
       <PolarSurfaceArea readOnly="false" value="0"/>
     </Physicochemicals>
   </Pharmacokinetics>
+  <Pharmacodynamics>
+    <Bronchodilation readOnly="false" value="0.3"/>
+    <DiastolicPressureModifier readOnly="false" value="-0.25"/>
+    <EC50 readOnly="false" unit="ug/mL" value="0.0009"/>
+    <EMaxShapeParameter readOnly="false" value="10"/>
+    <FeverModifier readOnly="false" value="0"/>
+    <HeartRateModifier readOnly="false" value="0.45"/>
+    <HemorrhageModifier readOnly="false" value="0"/>
+    <NeuromuscularBlock readOnly="false" value="0"/>
+    <PainModifier readOnly="false" value="0"/>
+    <PupillaryResponse>
+      <ReactivityModifier readOnly="false" value="0"/>
+      <SizeModifier readOnly="false" value="0.34"/>
+    </PupillaryResponse>
+    <RespirationRateModifier readOnly="false" value="0"/>
+    <Sedation readOnly="false" value="0"/>
+    <SystolicPressureModifier readOnly="false" value="0.5"/>
+    <TidalVolumeModifier readOnly="false" value="0"/>
+    <TubularPermeabilityModifier readOnly="false" value="0"/>
+    <CentralNervousModifier readOnly="false" value="0"/>
+    <AntibacterialEffect readOnly="false" unit="1/hr" value="0"/>
+    <EffectSiteRateConstant readOnly="false" unit="1/min" value="0"/>
+  </Pharmacodynamics>
 </Substance>