diff --git a/src/modules/api/pipeline-task/requirements.txt b/src/modules/api/pipeline-task/requirements.txt
old mode 100755
new mode 100644
index cda00515a..265e30fa2
--- a/src/modules/api/pipeline-task/requirements.txt
+++ b/src/modules/api/pipeline-task/requirements.txt
@@ -1,16 +1,16 @@
-Flask==1.1.2
+Flask==2.2.5
 backoff==2.2.1
 gcloud==0.18.3
 google_cloud_secret_manager==2.7.2
 google-api-python-client>=2.35.0
 google-cloud-datastore==2.2.0
 google-cloud-run
-gunicorn==20.1.0
+gunicorn==22.0.0
 python-dotenv==0.19.1
-sentry-sdk==1.7.2
+sentry-sdk==1.14.0
 itsdangerous==2.0.1
 pyOpenSSL==22.1.0
-Jinja2==3.0.3
-Werkzeug==1.0.0
+Jinja2==3.1.3
+Werkzeug==2.3.8
 Flask_SQLAlchemy==2.5.1
 SQLAlchemy==1.3.18
diff --git a/src/modules/db_operations/requirements.txt b/src/modules/db_operations/requirements.txt
index a6d363ce4..7a81efabf 100644
--- a/src/modules/db_operations/requirements.txt
+++ b/src/modules/db_operations/requirements.txt
@@ -1,14 +1,14 @@
 backoff==2.2.1
-Flask==1.1.2
+Flask==2.2.5
 Flask_SQLAlchemy==2.5.1
 SQLAlchemy==1.3.18
 logzero==1.3.1
 python-dotenv==0.19.1
 itsdangerous==2.0.1
-sentry-sdk==1.7.2
+sentry-sdk==1.14.0
 pg8000
 PyYAML>=4.2b1
 diskcache==5.4.0
 itsdangerous==2.0.1
-Jinja2==3.0.3
-Werkzeug==1.0.0
\ No newline at end of file
+Jinja2==3.1.3
+Werkzeug==2.3.8
\ No newline at end of file
diff --git a/src/modules/indel_primer/requirements.txt b/src/modules/indel_primer/requirements.txt
index 77ad7bb45..c5cb24295 100644
--- a/src/modules/indel_primer/requirements.txt
+++ b/src/modules/indel_primer/requirements.txt
@@ -1,5 +1,5 @@
 logzero==1.3.1
 python-dotenv==0.19.1
-sentry-sdk==1.7.2
+sentry-sdk==1.14.0
 itsdangerous==2.0.1
-Jinja2==3.0.3
+Jinja2==3.1.3
diff --git a/src/modules/maintenance/requirements.txt b/src/modules/maintenance/requirements.txt
index bfc964868..d31266fd3 100644
--- a/src/modules/maintenance/requirements.txt
+++ b/src/modules/maintenance/requirements.txt
@@ -1,8 +1,8 @@
-Flask==1.1.2
-Werkzeug==1.0.0
+Flask==2.2.5
+Werkzeug==2.3.8
 WTForms==2.1
 bleach==4.1.0
-Jinja2==3.0.3
+Jinja2==3.1.3
 itsdangerous==2.0.1
 pyOpenSSL==22.1.0
 gunicorn
\ No newline at end of file
diff --git a/src/modules/site-v2/requirements.txt b/src/modules/site-v2/requirements.txt
old mode 100755
new mode 100644
index 8c797feaa..e379afddc
--- a/src/modules/site-v2/requirements.txt
+++ b/src/modules/site-v2/requirements.txt
@@ -3,7 +3,7 @@ boto3
 cachelib
 click==6.7
 feedgen==0.9.0
-Flask==1.1.2
+Flask==2.2.5
 Flask_Caching==1.3.3
 Flask_Compress==1.13
 Flask-Dance==3.0.0
@@ -29,14 +29,14 @@ google_cloud_logging
 google-cloud-run
 grpcio
 gunicorn
-httplib2==0.18.0
+httplib2==0.19.0
 itsdangerous==2.0.1
 logzero==1.3.1
 Markdown==2.6.11
 pandas==1.1.3
 peewee==2.10.2
 psycopg2-binary>=2.9.1
-pyarrow==0.17.1
+pyarrow==14.0.1
 pyOpenSSL==22.1.0
 pytabix
 python_dateutil==2.7.3
@@ -45,14 +45,14 @@ pytz==2017.3
 PyYAML>=4.2b1
 requests
 rich
-sentry-sdk==1.7.2
+sentry-sdk==1.14.0
 setuptools>=40.3.0
 scipy
 simplejson==3.13.2
 SQLAlchemy==1.3.18
 unicode_slugify==0.1.3
-Werkzeug==1.0.0
+Werkzeug==2.3.8
 WTForms==2.1
 bleach==4.1.0
-Jinja2==3.0.3
+Jinja2==3.1.3
 
diff --git a/src/modules/site/requirements.txt b/src/modules/site/requirements.txt
old mode 100755
new mode 100644
index bd1c8e817..b154948fe
--- a/src/modules/site/requirements.txt
+++ b/src/modules/site/requirements.txt
@@ -3,7 +3,7 @@ boto3
 cachelib
 click==6.7
 feedgen==0.9.0
-Flask==1.1.2
+Flask==2.2.5
 Flask_Caching==1.3.3
 Flask-Dance==3.0.0
 Flask_DebugToolbar==0.10.1
@@ -26,14 +26,14 @@ google-cloud-datastore
 google_cloud_logging
 grpcio
 gunicorn
-httplib2==0.18.0
+httplib2==0.19.0
 itsdangerous==2.0.1
 logzero==1.3.1
 Markdown==2.6.11
 pandas==1.0.5
 peewee==2.10.2
 psycopg2-binary>=2.9.1
-pyarrow==0.17.1
+pyarrow==14.0.1
 pyOpenSSL==22.1.0
 pytabix
 python_dateutil==2.6.1
@@ -42,13 +42,13 @@ pytz==2017.3
 PyYAML>=4.2b1
 requests
 rich
-sentry-sdk==1.7.2
+sentry-sdk==1.14.0
 setuptools>=40.3.0
 scipy
 simplejson==3.13.2
 SQLAlchemy==1.3.18
 unicode_slugify==0.1.3
-Werkzeug==1.0.0
+Werkzeug==2.3.8
 WTForms==2.1
 bleach==4.1.0
-Jinja2==3.0.3
+Jinja2==3.1.3
diff --git a/src/pkg/caendr/requirements.dev.txt b/src/pkg/caendr/requirements.dev.txt
index 40e63af8d..0d8d922d6 100644
--- a/src/pkg/caendr/requirements.dev.txt
+++ b/src/pkg/caendr/requirements.dev.txt
@@ -1,7 +1,7 @@
 backoff==2.2.1
 cachelib
 Flask_SQLAlchemy==2.5.1
-Flask==1.1.2
+Flask==2.2.5
 google-api-python-client
 google-cloud-datastore
 google_cloud_logging
@@ -18,6 +18,6 @@ pandas
 plotly==5.3.0
 psycopg2-binary>=2.9.1
 python-dotenv==0.19.1
-sentry-sdk==1.7.2
-Jinja2==3.0.3
-Werkzeug==1.0.0
\ No newline at end of file
+sentry-sdk==1.14.0
+Jinja2==3.1.3
+Werkzeug==2.3.8
\ No newline at end of file
diff --git a/src/pkg/caendr/setup.py b/src/pkg/caendr/setup.py
index a377c1778..726d06ba2 100644
--- a/src/pkg/caendr/setup.py
+++ b/src/pkg/caendr/setup.py
@@ -9,7 +9,7 @@
     'cachelib',
     'cyvcf2==0.30.22',
     'Flask_SQLAlchemy==2.5.1',
-    'Flask==1.1.2',
+    'Flask==2.2.5',
     'protobuf==3.20.2',
     'google-cloud-appengine-logging==0.1.0',
     'google_cloud_audit_log==0.2.5',
@@ -24,7 +24,7 @@
     'gtfparse==0.0.6',
     'logzero==1.3.1',
     'oauth2client',
-    'numpy==1.19.5',
+    'numpy==1.22.0',
     'pandas==1.1.3',
     'plotly==5.3.0',
     'psycopg2-binary>=2.9.1',
@@ -33,6 +33,6 @@
     'pytabix==0.1',
     'importlib; python_version == "3.8.10"',
     'scipy',
-    'Werkzeug==1.0.0'
+    'Werkzeug==2.3.8'
   ],
 )